Mzb1 MGI Mouse Gene Detail - MGI:1917066 - marginal zone B and B1 cell-specific protein 1

Symbol

Mzb1
Name

marginal zone B and B1 cell-specific protein 1
Synonyms

2010001M09Rik, pERp1

Feature Type

protein coding gene
IDs

MGI:1917066
NCBI Gene: 69816
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr18:35780320-35782420 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.19 cM
Mapping Data

2 experiments

SNPs within 2kb

149 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917066	protein coding gene	Chr18:35780318-35782420 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024264	protein coding gene	Chr18:33967636-33969737 (-)
A/J	MGP_AJ_G0024230	protein coding gene	Chr18:32800571-32802672 (-)
AKR/J	MGP_AKRJ_G0024198	protein coding gene	Chr18:33723845-33725946 (-)
BALB/cJ	MGP_BALBcJ_G0024230	protein coding gene	Chr18:32845255-32847356 (-)
C3H/HeJ	MGP_C3HHeJ_G0023997	protein coding gene	Chr18:33750292-33752396 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024671	protein coding gene	Chr18:35188989-35191090 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022111	protein coding gene	Chr18:32904876-32906979 (-)
CAST/EiJ	MGP_CASTEiJ_G0023472	protein coding gene	Chr18:33737441-33739525 (-)
CBA/J	MGP_CBAJ_G0023965	protein coding gene	Chr18:36200388-36202489 (-)
DBA/2J	MGP_DBA2J_G0024097	protein coding gene	Chr18:32432512-32434613 (-)
FVB/NJ	MGP_FVBNJ_G0024064	protein coding gene	Chr18:32118632-32120733 (-)
LP/J	MGP_LPJ_G0024179	protein coding gene	Chr18:34022734-34024835 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024092	protein coding gene	Chr18:37437955-37440059 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024720	protein coding gene	Chr18:33561681-33563782 (-)
PWK/PhJ	MGP_PWKPhJ_G0023216	protein coding gene	Chr18:32656086-32658179 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023023	protein coding gene	Chr18:33825045-33827159 (-)
WSB/EiJ	MGP_WSBEiJ_G0023535	protein coding gene	Chr18:33482182-33484283 (-)

Human Ortholog

MZB1, marginal zone B and B1 cell specific protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MZB1, marginal zone B and B1 cell specific protein
Synonyms

MEDA-7, PACAP, pERp1
Links

HGNC:30125

NCBI Gene ID: 51237

neXtProt AC: NX_Q8WU39

UniProt: Q8WU39
Chr Location

5q31.2; chr5:139387467-139390081 (-) GRCh38

MGI Vertebrate Homology

Mzb1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MZB1
Gene Tree

Mzb1

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Constitutive and B cell specific conditional homozygous KO impairs the immune response by affecting B cell maturation.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

28
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS29145.1

Ensembl

ENSMUSG00000024353 (Evidence)
NCBI Gene

69816

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024353	Ensembl Gene Model \| MGI Sequence Detail	2101	C57BL/6J	± kb
transcript	ENSMUST00000025211	Ensembl \| MGI Sequence Detail	904	Not Applicable
polypeptide	ENSMUSP00000025211	Ensembl \| MGI Sequence Detail	188	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012212 proapoptotic caspase adapter protein

(term hierarchy)
InterPro Domains

IPR021852 Domain of unknown function DUF3456

IPR052682 Marginal zone B- and B1-cell-specific protein

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All nucleic 28

cDNA 28

Microarray probesets 3

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MGI:2147333

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mzb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152891	Chr18:35782622-35782642 (-)	-212 bp
Tssr152890	Chr18:35782545-35782552 (-)	-129 bp
Tssr152889	Chr18:35782402-35782427 (-)	5 bp
Tssr152888	Chr18:35782388-35782397 (-)	27 bp
Tssr152887	Chr18:35782365-35782381 (-)	47 bp
Tssr152886	Chr18:35781560-35781569 (-)	855 bp
Tssr152885	Chr18:35781536-35781555 (-)	874 bp
Tssr152884	Chr18:35781519-35781535 (-)	893 bp
Tssr152883	Chr18:35781469-35781483 (-)	944 bp
Tssr152882	Chr18:35781450-35781465 (-)	962 bp
Tssr152881	Chr18:35781432-35781448 (-)	980 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24