Rab43 MGI Mouse Gene Detail - MGI:1917084 - RAB43, member RAS oncogene family

Symbol

Rab43
Name

RAB43, member RAS oncogene family
Synonyms

1810048P08Rik, 2500004H21Rik

Feature Type

protein coding gene
IDs

MGI:1917084
NCBI Gene: 69834
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:87765835-87789146 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 39.13 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

545 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917084	protein coding gene	Chr6:87765835-87789146 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030998	protein coding gene	Chr6:89153695-89180131 (-)
A/J	MGP_AJ_G0030964	protein coding gene	Chr6:85713200-85736592 (-)
AKR/J	MGP_AKRJ_G0030895	protein coding gene	Chr6:88192064-88215245 (-)
BALB/cJ	MGP_BALBcJ_G0030977	protein coding gene	Chr6:85708419-85731543 (-)
C3H/HeJ	MGP_C3HHeJ_G0030733	protein coding gene	Chr6:96256583-96279862 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031434	protein coding gene	Chr6:91544976-91568252 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028617	protein coding gene	Chr6:83885926-83909051 (-)
CAST/EiJ	MGP_CASTEiJ_G0030086	protein coding gene	Chr6:88272554-88295728 (-)
CBA/J	MGP_CBAJ_G0030661	protein coding gene	Chr6:95089369-95112603 (-)
DBA/2J	MGP_DBA2J_G0030817	protein coding gene	Chr6:85013179-85036487 (-)
FVB/NJ	MGP_FVBNJ_G0030770	protein coding gene	Chr6:84199847-84224005 (-)
LP/J	MGP_LPJ_G0030894	protein coding gene	Chr6:89170929-89198765 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030803	protein coding gene	Chr6:99225707-99248832 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031461	protein coding gene	Chr6:88045174-88068420 (-)
PWK/PhJ	MGP_PWKPhJ_G0029801	protein coding gene	Chr6:83981089-84004821 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029629	protein coding gene	Chr6:86861073-86884204 (-)
WSB/EiJ	MGP_WSBEiJ_G0030167	protein coding gene	Chr6:88495108-88520104 (-)

Human Ortholog

RAB43, RAB43, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB43, RAB43, member RAS oncogene family
Synonyms

RAB11B, RAB41
Links

HGNC:19983

NCBI Gene ID: 339122

neXtProt AC: NX_Q86YS6

UniProt: Q86YS6
Chr Location

3q21.3; chr3:129087569-129122801 (-) GRCh38

MGI Vertebrate Homology

Rab43 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB43
Gene Tree

Rab43

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Rab43
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit defects in dendritic cell antigen presentation.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

24
cDNA Data

67
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab43

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All Sequences

66
RefSeq

6
UniProt

5
CCDS

CCDS20329.1, CCDS20330.1

Ensembl

ENSMUSG00000030055 (Evidence)
NCBI Gene

69834

			Length	Strain/Species	Flank
genomic	69834	NCBI Gene Model \| MGI Sequence Detail	23312	C57BL/6J	± kb
transcript	NM_001039394	RefSeq \| MGI Sequence Detail	4605	C57BL/6
polypeptide	Q8CG50	UniProt \| EBI \| MGI Sequence Detail	210	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013630 Ras-related protein Rab-43

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR048040 Rab GTPase 19/43

IPR050209 Rab GTPases family involved in membrane trafficking

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 67

cDNA 67

Microarray probesets 5

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MGI:1917339, MGI:2141679

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab43:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61941	Chr6:87788792-87788824 (-)	338 bp
Tssr61940	Chr6:87788753-87788784 (-)	377 bp
Tssr61939	Chr6:87788634-87788649 (-)	504 bp
Tssr61938	Chr6:87786774-87786796 (-)	2,361 bp
Tssr61937	Chr6:87786751-87786769 (-)	2,386 bp
Tssr1926	Chr6:87768430-87768445 (-)	20,708 bp
Tssr61935	Chr6:87767243-87767253 (-)	21,898 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24