Eif1ad MGI Mouse Gene Detail - MGI:1917110 - eukaryotic translation initiation factor 1A domain containing

Symbol

Eif1ad
Name

eukaryotic translation initiation factor 1A domain containing
Synonyms

2010003J03Rik, Eif1ad1

Feature Type

protein coding gene
IDs

MGI:1917110
NCBI Gene: 69860
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:5416841-5421546 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.31 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

154 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917110	protein coding gene	Chr19:5416769-5421554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024701	protein coding gene	Chr19:2324283-2328981 (+)
A/J	MGP_AJ_G0024667	protein coding gene	Chr19:2200029-2204734 (+)
AKR/J	MGP_AKRJ_G0024640	protein coding gene	Chr19:2261903-2266608 (+)
BALB/cJ	MGP_BALBcJ_G0024667	protein coding gene	Chr19:2196124-2200829 (+)
C3H/HeJ	MGP_C3HHeJ_G0024435	protein coding gene	Chr19:2267656-2272361 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025114	protein coding gene	Chr19:2384049-2388747 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022544	protein coding gene	Chr19:2106336-2110990 (+)
CAST/EiJ	MGP_CASTEiJ_G0023907	protein coding gene	Chr19:2295516-2300225 (+)
CBA/J	MGP_CBAJ_G0024407	protein coding gene	Chr19:2485685-2490387 (+)
DBA/2J	MGP_DBA2J_G0024534	protein coding gene	Chr19:2179138-2183852 (+)
FVB/NJ	MGP_FVBNJ_G0024501	protein coding gene	Chr19:2187401-2192102 (+)
LP/J	MGP_LPJ_G0024620	protein coding gene	Chr19:2307410-2312108 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024531	protein coding gene	Chr19:2341504-2346209 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025162	protein coding gene	Chr19:2262985-2267683 (+)
PWK/PhJ	MGP_PWKPhJ_G0023653	protein coding gene	Chr19:2217596-2222494 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023458	protein coding gene	Chr19:2253153-2257886 (+)
WSB/EiJ	MGP_WSBEiJ_G0023969	protein coding gene	Chr19:2280312-2285046 (+)

Human Ortholog

EIF1AD, eukaryotic translation initiation factor 1A domain containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF1AD, eukaryotic translation initiation factor 1A domain containing
Synonyms

haponin, OBELIX
Links

HGNC:28147

NCBI Gene ID: 84285

neXtProt AC: NX_Q8N9N8

UniProt: Q8N9N8
Chr Location

11q13.1; chr11:65996545-66002176 (-) GRCh38

MGI Vertebrate Homology

Eif1ad stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF1AD
Gene Tree

Eif1ad

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Gene trapped

17
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

28
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif1ad

ZFIN eif1ad

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All Sequences

44
RefSeq

4
UniProt

1
CCDS

CCDS29459.1

Ensembl

ENSMUSG00000024841 (Evidence)
NCBI Gene

69860

			Length	Strain/Species	Flank
genomic	69860	NCBI Gene Model \| MGI Sequence Detail	4706	C57BL/6J	± kb
transcript	NM_027236	RefSeq \| MGI Sequence Detail	2469	C57BL/6
polypeptide	Q3THJ3	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029444 probable RNA-binding protein EIF1AD

(term hierarchy)
InterPro Domains

IPR012340 Nucleic acid-binding, OB-fold

IPR039294 Probable RNA-binding protein EIF1AD

IPR006196 RNA-binding domain, S1, IF1 type

IPR001253 Translation initiation factor 1A (eIF-1A)

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All nucleic 13

cDNA 13

Microarray probesets 5

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MGI:2147479

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eif1ad:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154405	Chr19:5416415-5416449 (+)	-409 bp
Tssr154406	Chr19:5416792-5416879 (+)	-5 bp
Tssr154407	Chr19:5416976-5416990 (+)	142 bp
Tssr154408	Chr19:5416993-5417065 (+)	188 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24