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A1cf Gene Detail
Summary
  • Symbol
    A1cf
  • Name
    APOBEC1 complementation factor
  • Synonyms
    1810073H04Rik, ACF, apobec-1 complementation factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917115
    NCBI Gene: 69865
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:31846164-31926395 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 26.58 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1973 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917115
 protein coding gene Chr19:31846156-31929765 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025037
 protein coding gene Chr19:30479481-30560179 (+)
A/J MGP_AJ_G0025014
 protein coding gene Chr19:28959076-29038407 (+)
AKR/J MGP_AKRJ_G0024982
 protein coding gene Chr19:29979925-30063964 (+)
BALB/cJ MGP_BALBcJ_G0025013
 protein coding gene Chr19:29000374-29084609 (+)
C3H/HeJ MGP_C3HHeJ_G0024769
 protein coding gene Chr19:29961898-30044401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025454
 protein coding gene Chr19:31306992-31398832 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022873
 protein coding gene Chr19:28883884-28955331 (+)
CAST/EiJ MGP_CASTEiJ_G0024240
 protein coding gene Chr19:29847942-29933668 (+)
CBA/J MGP_CBAJ_G0024747
 protein coding gene Chr19:32771578-32863197 (+)
DBA/2J MGP_DBA2J_G0024879
 protein coding gene Chr19:28892054-28965768 (+)
FVB/NJ MGP_FVBNJ_G0024841
 protein coding gene Chr19:28707590-28788497 (+)
LP/J MGP_LPJ_G0024964
 protein coding gene Chr19:30483995-30570105 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024868
 protein coding gene Chr19:32691292-32776493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025509
 protein coding gene Chr19:30012212-30101280 (+)
PWK/PhJ MGP_PWKPhJ_G0023988
 protein coding gene Chr19:28577824-28648671 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023792
 protein coding gene Chr19:29352463-29435425 (+)
WSB/EiJ MGP_WSBEiJ_G0024306
 protein coding gene Chr19:30057082-30135769 (+)



Homology
more
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
  • Synonyms
    ACF, ACF64, ACF65, APOBEC1CF, ASP
  • Links
    NCBI Gene ID: 29974
    neXtProt AC: NX_Q9NQ94
    UniProt: Q9NQ94

  • Chr Location
    10q11.23; chr10:50799409-50885675 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human A1CF associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    139 phenotypes from multigenic genotypes
    6 images
    521 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted deletion of this gene are detectable only until the blastocyst stage (E3.5) and isolated mutant blastocysts fail to proliferate in vitro. Mice homozygous for a conditional allele activated in the liver exhibit altered fructose and glycerol metabolism. Mice homozygous for a different null allele exhibit normal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    33
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052595 Ensembl Gene Model | MGI Sequence Detail 80232 C57BL/6J ±  kb
    transcript ENSMUST00000075838 Ensembl | MGI Sequence Detail 3414 Not Applicable  
    polypeptide ENSMUSP00000075235 Ensembl | MGI Sequence Detail 595 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3050446
    References
    more
    • Summaries
      All 558
      Developmental Gene Expression 3
      Diseases 9
      Gene Ontology 15
      Phenotypes 521
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:359431 Waypa GB, et al., Mitochondria regulate proliferation in adult cardiac myocytes. J Clin Invest. 2024 May 9;134(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory