Cfap74 MGI Mouse Gene Detail - MGI:1917130 - cilia and flagella associated protein 74

Symbol

Cfap74
Name

cilia and flagella associated protein 74
Synonyms

2010015L04Rik

Feature Type

protein coding gene
IDs

MGI:1917130
NCBI Gene: 544678
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:155493647-155551280 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.17 cM
Mapping Data

1 experiment

SNPs within 2kb

1781 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917130	protein coding gene	Chr4:155493647-155551280 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029213	protein coding gene	Chr4:159733384-159799587 (+)
A/J	MGP_AJ_G0029178	protein coding gene	Chr4:153026012-153086206 (+)
AKR/J	MGP_AKRJ_G0029126	protein coding gene	Chr4:157185292-157245834 (+)
BALB/cJ	MGP_BALBcJ_G0029194	protein coding gene	Chr4:153496448-153555860 (+)
C3H/HeJ	MGP_C3HHeJ_G0028915	protein coding gene	Chr4:157728084-157791852 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029643	protein coding gene	Chr4:165420416-165487949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026889	protein coding gene	Chr4:145319774-145377535 (+)
CAST/EiJ	MGP_CASTEiJ_G0028328	protein coding gene	Chr4:155167405-155228296 (+)
CBA/J	MGP_CBAJ_G0028877	protein coding gene	Chr4:170394506-170475825 (+)
DBA/2J	MGP_DBA2J_G0029026	protein coding gene	Chr4:153041133-153105647 (+)
FVB/NJ	MGP_FVBNJ_G0028990	protein coding gene	Chr4:152284090-152345036 (+)
LP/J	MGP_LPJ_G0029116	protein coding gene	Chr4:159658222-159722796 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029017	protein coding gene	Chr4:173241413-173304731 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029675	protein coding gene	Chr4:157796920-157864585 (+)
PWK/PhJ	MGP_PWKPhJ_G0028048	protein coding gene	Chr4:149176301-149239996 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027882	protein coding gene	Chr4:152066508-152126880 (+)
WSB/EiJ	MGP_WSBEiJ_G0028408	protein coding gene	Chr4:157970749-158038164 (+)

Human Ortholog

CFAP74, cilia and flagella associated protein 74

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CFAP74, cilia and flagella associated protein 74
Synonyms

C1orf222, CILD49, KIAA1751
Links

HGNC:29368

NCBI Gene ID: 85452

neXtProt AC: NX_Q9C0B2

UniProt: Q9C0B2
Chr Location

1p36.33; chr1:1921951-2003837 (-) GRCh38

MGI Vertebrate Homology

Cfap74 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CFAP74
Gene Tree

Cfap74

Diseases

1 with human CFAP74 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia IDs primary ciliary dyskinesia DOID:9562 DOID:2925 MESH:D002925 NCI:C84638 OMIM:PS244400 ORDO:244 UMLS_CUI:C0008780

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cfap74

ZFIN cfap74

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All Sequences

70
RefSeq

24
UniProt

1
CCDS

CCDS38993.1, CCDS51402.1, CCDS89870.1

Ensembl

ENSMUSG00000078490 (Evidence)
NCBI Gene

544678

			Length	Strain/Species	Flank
genomic	544678	NCBI Gene Model \| MGI Sequence Detail	57634	C57BL/6J	± kb
transcript	NM_001368738	RefSeq \| MGI Sequence Detail	5640	C57BL/6
polypeptide	Q3UY96	UniProt \| EBI \| MGI Sequence Detail	1578	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000060062 cilia- and flagella-associated protein 74

(term hierarchy)
GlyGen

Q3UY96 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 26

Gene Ontology 2

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cfap74:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40636	Chr4:155493658-155493723 (+)	44 bp
Tssr40637	Chr4:155493727-155493737 (+)	85 bp
Tssr40638	Chr4:155493743-155493746 (+)	98 bp
Tssr40639	Chr4:155499379-155499408 (+)	5,747 bp
Tssr40640	Chr4:155499434-155499443 (+)	5,792 bp
Tssr40641	Chr4:155499468-155499475 (+)	5,825 bp
Tssr40642	Chr4:155551051-155551061 (+)	57,409 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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