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Fndc4 Gene Detail
Summary
  • Symbol
    Fndc4
  • Name
    fibronectin type III domain containing 4
  • Synonyms
    2810430J06Rik, 6330410H20Rik, FRCP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917195
    NCBI Gene: 64339
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31449589-31453279 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917195
 protein coding gene Chr5:31449586-31453424 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029423
 protein coding gene Chr5:29290348-29294186 (-)
A/J MGP_AJ_G0029389
 protein coding gene Chr5:28324382-28328220 (-)
AKR/J MGP_AKRJ_G0029339
 protein coding gene Chr5:29474379-29478217 (-)
BALB/cJ MGP_BALBcJ_G0029400
 protein coding gene Chr5:28838397-28842235 (-)
C3H/HeJ MGP_C3HHeJ_G0029121
 protein coding gene Chr5:29505037-29508875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029853
 protein coding gene Chr5:31099290-31103128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027091
 protein coding gene Chr5:25973398-25977176 (-)
CAST/EiJ MGP_CASTEiJ_G0028531
 protein coding gene Chr5:28577940-28581778 (-)
CBA/J MGP_CBAJ_G0029089
 protein coding gene Chr5:31677026-31680864 (-)
DBA/2J MGP_DBA2J_G0029238
 protein coding gene Chr5:28501837-28505675 (-)
FVB/NJ MGP_FVBNJ_G0029196
 protein coding gene Chr5:27918867-27922705 (-)
LP/J MGP_LPJ_G0029323
 protein coding gene Chr5:29739830-29743668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029225
 protein coding gene Chr5:32539530-32543368 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029887
 protein coding gene Chr5:28989864-28993702 (-)
PWK/PhJ MGP_PWKPhJ_G0028256
 protein coding gene Chr5:27625870-27629719 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028087
 protein coding gene Chr5:28383318-28387184 (-)
WSB/EiJ MGP_WSBEiJ_G0028612
 protein coding gene Chr5:29054378-29058216 (-)



Homology
more
  • Human Ortholog
    FNDC4, fibronectin type III domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FNDC4, fibronectin type III domain containing 4
  • Synonyms
    FRCP1
  • Links
    NCBI Gene ID: 64838
    neXtProt AC: NX_Q9H6D8
    UniProt: Q9H6D8

  • Chr Location
    2p23.3; chr2:27491883-27495200 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice suffer from increased severity of DSS-induced colitis with increased weight loss and decreased colon length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    22
  • cDNA Data
    28
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64339 NCBI Gene Model | MGI Sequence Detail 3691 C57BL/6J ±  kb
    transcript NM_001356945 RefSeq | MGI Sequence Detail 2343 C57BL/6  
    polypeptide Q3TR08 UniProt | EBI | MGI Sequence Detail 231 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921251, MGI:1927605, MGI:2140974, MGI:2141194
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:354023 Xu X, et al., Fibronectin type III domain containing 4 alleviates myocardial ischemia/reperfusion injury via the Nrf2-dependent antioxidant pathway. Free Radic Biol Med. 2024 Aug 26;224:256-271
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory