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Spink2 Gene Detail
Summary
  • Symbol
    Spink2
  • Name
    serine peptidase inhibitor, Kazal type 2
  • Synonyms
    1700007F22Rik, acrosin-trypsin inhibitor, HUSI-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917232
    NCBI Gene: 69982
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77352954-77359318 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917232
 protein coding gene Chr5:77352953-77364106 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029655
 protein coding gene Chr5:77456042-77464742 (-)
A/J MGP_AJ_G0029623
 protein coding gene Chr5:74473973-74481191 (-)
AKR/J MGP_AKRJ_G0029571
 protein coding gene Chr5:76921059-76927011 (-)
BALB/cJ MGP_BALBcJ_G0029632
 protein coding gene Chr5:75214834-75220662 (-)
C3H/HeJ MGP_C3HHeJ_G0029355
 protein coding gene Chr5:77276056-77283968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030086
 protein coding gene Chr5:80545417-80551231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027327
 protein coding gene Chr5:70198764-70204782 (-)
CAST/EiJ MGP_CASTEiJ_G0028763
 protein coding gene Chr5:76502814-76508623 (-)
CBA/J MGP_CBAJ_G0029324
 protein coding gene Chr5:83204822-83214934 (-)
DBA/2J MGP_DBA2J_G0029469
 protein coding gene Chr5:74533709-74540137 (-)
FVB/NJ MGP_FVBNJ_G0029430
 protein coding gene Chr5:73737955-73743973 (-)
LP/J MGP_LPJ_G0029556
 protein coding gene Chr5:77874967-77882450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029458
 protein coding gene Chr5:86310586-86318063 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030119
 protein coding gene Chr5:76466122-76472629 (-)
PWK/PhJ MGP_PWKPhJ_G0028486
 protein coding gene Chr5:73552966-73559245 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028321
 protein coding gene Chr5:75832549-75838110 (-)
WSB/EiJ MGP_WSBEiJ_G0028843
 protein coding gene Chr5:76787894-76795439 (-)



Homology
more
  • Human Ortholog
    SPINK2, serine peptidase inhibitor Kazal type 2
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK2, serine peptidase inhibitor Kazal type 2
  • Synonyms
    HUSI-II, SPGF29
  • Links
    NCBI Gene ID: 6691
    neXtProt AC: NX_P20155
    UniProt: P20155

  • Chr Location
    4q12; chr4:56809860-56821869 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPINK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced male fertility associated with oligozoospermia, teratozoospermia, male germ cell apoptosis, and small testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    11
  • cDNA Data
    47
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053030 Ensembl Gene Model | MGI Sequence Detail 6365 C57BL/6J ±  kb
    transcript ENSMUST00000065216 Ensembl | MGI Sequence Detail 631 Not Applicable  
    polypeptide ENSMUSP00000067117 Ensembl | MGI Sequence Detail 86 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141109
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory