Acot7 MGI Mouse Gene Detail - MGI:1917275

Symbol

Acot7
Name

acyl-CoA thioesterase 7
Synonyms

2410041A17Rik, AU014716, Bach

Feature Type

protein coding gene
IDs

MGI:1917275
NCBI Gene: 70025
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr4:152262591-152356312 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 82.93 cM
Mapping Data

2 experiments

SNPs within 2kb

2441 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917275	protein coding gene	Chr4:152258872-152356312 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029175	protein coding gene	Chr4:156280425-156379395 (+)
A/J	MGP_AJ_G0029140	protein coding gene	Chr4:149728495-149829962 (+)
AKR/J	MGP_AKRJ_G0029088	protein coding gene	Chr4:153798479-153901511 (+)
BALB/cJ	MGP_BALBcJ_G0029156	protein coding gene	Chr4:150201611-150297492 (+)
C3H/HeJ	MGP_C3HHeJ_G0028877	protein coding gene	Chr4:154367626-154465750 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029605	protein coding gene	Chr4:161877994-161995012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026851	protein coding gene	Chr4:142081689-142171044 (+)
CAST/EiJ	MGP_CASTEiJ_G0028290	protein coding gene	Chr4:151715227-151819975 (+)
CBA/J	MGP_CBAJ_G0028839	protein coding gene	Chr4:166696138-166823658 (+)
DBA/2J	MGP_DBA2J_G0028988	protein coding gene	Chr4:149780772-149882997 (+)
FVB/NJ	MGP_FVBNJ_G0028952	protein coding gene	Chr4:148941130-149042250 (+)
LP/J	MGP_LPJ_G0029078	protein coding gene	Chr4:156197284-156303727 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028979	protein coding gene	Chr4:169731221-169835942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029637	protein coding gene	Chr4:154339136-154439322 (+)
PWK/PhJ	MGP_PWKPhJ_G0028010	protein coding gene	Chr4:145854372-145949783 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027844	protein coding gene	Chr4:148621681-148726703 (+)
WSB/EiJ	MGP_WSBEiJ_G0028370	protein coding gene	Chr4:154520264-154620792 (+)

Human Ortholog

ACOT7, acyl-CoA thioesterase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT7, acyl-CoA thioesterase 7
Synonyms

ACH1, ACT, BACH, CTE-II, hBACH, LACH, LACH1
Links

HGNC:24157

NCBI Gene ID: 11332

neXtProt AC: NX_O00154

UniProt: O00154
Chr Location

1p36.31; chr1:6264269-6393767 (-) GRCh38

MGI Vertebrate Homology

Acot7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACOT7
Gene Tree

Acot7

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Phenotype Summary

25 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

83
Endonuclease-mediated

2
Gene trapped

74
Targeted

7
Genomic Mutations

3 involving Acot7
Incidental Mutations

APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a floxed allele activated in neurons exhibit abnormal glucose and lipid homeostasis, altered metabolism, increaased adiposity, decreased lean mass, progressive neurodegeneration, and neurological defects in aged mice.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

971
Tissues

156
cDNA Data

107
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acot7

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All Sequences

80
RefSeq

24
UniProt

2
CCDS

CCDS51390.1, CCDS51391.2, CCDS51392.1

Ensembl

ENSMUSG00000028937 (Evidence)
NCBI Gene

70025

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028937	Ensembl Gene Model \| MGI Sequence Detail	93722	C57BL/6J	± kb
transcript	ENSMUST00000167926	Ensembl \| MGI Sequence Detail	1505	Not Applicable
polypeptide	ENSMUSP00000129121	Ensembl \| MGI Sequence Detail	384	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003638 cytosolic acyl coenzyme A thioester hydrolase

(term hierarchy)
PDB

2Q2B, 2V1O, 4ZV3, 6VFY
EC

3.1.2.2
InterPro Domains

IPR040170 Cytosolic acyl coenzyme A thioester hydrolase

IPR033120 Hotdog acyl-CoA thioesterase (ACOT)-type domain

IPR029069 HotDog domain superfamily

IPR006683 Thioesterase domain
GlyGen

Q91V12 1 site, 1 O-linked glycan (1 site)

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All nucleic 110

cDNA 109

Primer pair 1

Microarray probesets 3

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MGI:2140421, MGI:2140425, MGI:2140481, MGI:2140603

Summaries

All 56

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Acot7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40515	Chr4:152262269-152262284 (+)	-314 bp
Tssr40516	Chr4:152262402-152262408 (+)	-186 bp
Tssr40517	Chr4:152262414-152262470 (+)	-149 bp
Tssr40518	Chr4:152262473-152262487 (+)	-111 bp
Tssr40519	Chr4:152262492-152262501 (+)	-94 bp
Tssr40520	Chr4:152262562-152262569 (+)	-25 bp
Tssr40521	Chr4:152262583-152262623 (+)	12 bp
Tssr40522	Chr4:152262630-152262665 (+)	57 bp
Tssr40523	Chr4:152262667-152262687 (+)	86 bp
Tssr40524	Chr4:152262694-152262716 (+)	114 bp
Tssr40525	Chr4:152270452-152270463 (+)	7,867 bp
Tssr40526	Chr4:152270511-152270551 (+)	7,940 bp
Tssr40527	Chr4:152270636-152270663 (+)	8,059 bp
Tssr40528	Chr4:152274505-152274537 (+)	11,930 bp
Tssr40529	Chr4:152274961-152274987 (+)	12,383 bp
Tssr40530	Chr4:152284262-152284278 (+)	21,679 bp
Tssr40531	Chr4:152284279-152284329 (+)	21,713 bp
Tssr1390	Chr4:152284346-152284356 (+)	21,760 bp
Tssr40532	Chr4:152284453-152284496 (+)	21,884 bp
Tssr40533	Chr4:152301704-152301711 (+)	39,117 bp
Tssr1391	Chr4:152308799-152308840 (+)	46,229 bp
Tssr40534	Chr4:152326425-152326434 (+)	63,839 bp
Tssr40535	Chr4:152326471-152326480 (+)	63,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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