About   Help   FAQ
Meaf6 Gene Detail
Summary
  • Symbol
    Meaf6
  • Name
    MYST/Esa1-associated factor 6
  • Synonyms
    2310005N01Rik, 2810036M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917338
    NCBI Gene: 70088
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124978927-125007031 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 58.03 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    795 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917338
 protein coding gene Chr4:124978883-125007031 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028764
 protein coding gene Chr4:126670680-126702019 (+)
A/J MGP_AJ_G0028723
 protein coding gene Chr4:121690219-121718925 (+)
AKR/J MGP_AKRJ_G0028676
 protein coding gene Chr4:125027295-125054447 (+)
BALB/cJ MGP_BALBcJ_G0028746
 protein coding gene Chr4:122279675-122307998 (+)
C3H/HeJ MGP_C3HHeJ_G0028460
 protein coding gene Chr4:125107398-125135969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029188
 protein coding gene Chr4:131533500-131563673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026461
 protein coding gene Chr4:114855233-114883693 (+)
CAST/EiJ MGP_CASTEiJ_G0027893
 protein coding gene Chr4:123179020-123207720 (+)
CBA/J MGP_CBAJ_G0028426
 protein coding gene Chr4:134813620-134842450 (+)
DBA/2J MGP_DBA2J_G0028575
 protein coding gene Chr4:122160018-122188646 (+)
FVB/NJ MGP_FVBNJ_G0028542
 protein coding gene Chr4:120790066-120821803 (+)
LP/J MGP_LPJ_G0028676
 protein coding gene Chr4:126953553-126983036 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028568
 protein coding gene Chr4:139788675-139818287 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029226
 protein coding gene Chr4:125379428-125407446 (+)
PWK/PhJ MGP_PWKPhJ_G0027614
 protein coding gene Chr4:118592102-118620765 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027440
 protein coding gene Chr4:121166251-121200547 (+)
WSB/EiJ MGP_WSBEiJ_G0027973
 protein coding gene Chr4:125460870-125491247 (+)



Homology
more
  • Human Ortholog
    MEAF6, MYST/Esa1 associated factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEAF6, MYST/Esa1 associated factor 6
  • Synonyms
    C1orf149, CENP-28, EAF6, NY-SAR-91
  • Links
    NCBI Gene ID: 64769
    neXtProt AC: NX_Q9HAF1
    UniProt: Q9HAF1

  • Chr Location
    1p34.3; chr1:37489993-37514766 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Meaf6
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    43
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028863 Ensembl Gene Model | MGI Sequence Detail 28105 C57BL/6J ±  kb
transcript ENSMUST00000055213 Ensembl | MGI Sequence Detail 872 Not Applicable  
polypeptide ENSMUSP00000053543 Ensembl | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919914
References
more
  • Summaries
    All 43
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:303186 Matsuura K, et al., MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes. Exp Cell Res. 2020 Nov 1;396(1):112279
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory