Ube2q1 MGI Mouse Gene Detail - MGI:1917343 - ubiquitin-conjugating enzyme E2Q family member 1

Symbol

Ube2q1
Name

ubiquitin-conjugating enzyme E2Q family member 1
Synonyms

1110002C01Rik, 2310012M18Rik, NICE-5, PRO3094

Feature Type

protein coding gene
IDs

MGI:1917343
NCBI Gene: 70093
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:89680923-89691307 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.19 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

204 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917343	protein coding gene	Chr3:89680905-89691307 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027446	protein coding gene	Chr3:90009992-90020288 (+)
A/J	MGP_AJ_G0027410	protein coding gene	Chr3:87029356-87039652 (+)
AKR/J	MGP_AKRJ_G0027374	protein coding gene	Chr3:89143426-89153722 (+)
BALB/cJ	MGP_BALBcJ_G0027419	protein coding gene	Chr3:87000578-87010874 (+)
C3H/HeJ	MGP_C3HHeJ_G0027161	protein coding gene	Chr3:89336036-89346332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027865	protein coding gene	Chr3:93394665-93404961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025217	protein coding gene	Chr3:82517595-82527925 (+)
CAST/EiJ	MGP_CASTEiJ_G0026607	protein coding gene	Chr3:89711751-89722088 (+)
CBA/J	MGP_CBAJ_G0027135	protein coding gene	Chr3:96617708-96628004 (+)
DBA/2J	MGP_DBA2J_G0027273	protein coding gene	Chr3:86407859-86418155 (+)
FVB/NJ	MGP_FVBNJ_G0027241	protein coding gene	Chr3:84742735-84752926 (+)
LP/J	MGP_LPJ_G0027382	protein coding gene	Chr3:91079529-91089825 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027261	protein coding gene	Chr3:102791534-102808421 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027924	protein coding gene	Chr3:88892009-88902305 (+)
PWK/PhJ	MGP_PWKPhJ_G0026341	protein coding gene	Chr3:86291256-86301597 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026160	protein coding gene	Chr3:88078514-88088867 (+)
WSB/EiJ	MGP_WSBEiJ_G0026689	protein coding gene	Chr3:89292617-89302913 (+)

Human Ortholog

UBE2Q1, ubiquitin conjugating enzyme E2 Q1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2Q1, ubiquitin conjugating enzyme E2 Q1
Synonyms

GTAP, NICE-5, NICE5, PRO3094, UBE2Q
Links

HGNC:15698

NCBI Gene ID: 55585

neXtProt AC: NX_Q7Z7E8

UniProt: Q7Z7E8
Chr Location

1q21.3

MGI Vertebrate Homology

Ube2q1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UBE2Q1
Gene Tree

Ube2q1

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Ube2q1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit female-specific pleiotropic reproductive defects and partial embryonic lethality at implantation.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

21
cDNA Data

93
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

4
UniProt

1
CCDS

CCDS17517.1

Ensembl

ENSMUSG00000042572 (Evidence)
NCBI Gene

70093

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042572	Ensembl Gene Model \| MGI Sequence Detail	10385	C57BL/6J	± kb
transcript	ENSMUST00000038356	Ensembl \| MGI Sequence Detail	3077	Not Applicable
polypeptide	ENSMUSP00000037939	Ensembl \| MGI Sequence Detail	422	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016984 ubiquitin-conjugating enzyme E2 Q1

(term hierarchy)
EC

2.3.2.23
InterPro Domains

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 95

cDNA 94

Primer pair 1

Microarray probesets 5

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MGI:1915820, MGI:2139834

Summaries

All 38

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Ube2q1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30135	Chr3:89680650-89680701 (+)	-247 bp
Tssr30136	Chr3:89680869-89680949 (+)	-14 bp
Tssr30137	Chr3:89689580-89689623 (+)	8,679 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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