Lypd8 Gene Detail

Summary

• Symbol
  Lypd8
• Name
  LY6/PLAUR domain containing 8
• Synonyms
  2210415F13Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1917413
  NCBI Gene: 70163
• Alliance
  gene page
• Transcription Start Sites
  23 TSS

Location &
Maps

• Sequence Map
  Chr11:58269869-58281365 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 36.19 cM, cytoband B2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  398 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917413	protein coding gene	Chr11:58269869-58281554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018351	protein coding gene	Chr11:58102246-58115044 (+)
A/J	MGP_AJ_G0018321	protein coding gene	Chr11:55873494-55885163 (+)
AKR/J	MGP_AKRJ_G0018290	protein coding gene	Chr11:57703358-57715823 (+)
BALB/cJ	MGP_BALBcJ_G0018292	protein coding gene	Chr11:56210877-56222931 (+)
C3H/HeJ	MGP_C3HHeJ_G0018103	protein coding gene	Chr11:57647341-57659544 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018743	protein coding gene	Chr11:59877907-59891178 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016393	protein coding gene	Chr11:53220807-53232215 (+)
CAST/EiJ	MGP_CASTEiJ_G0017668	protein coding gene	Chr11:57738357-57753661 (+)
CBA/J	MGP_CBAJ_G0018078	protein coding gene	Chr11:62633531-62645281 (+)
DBA/2J	MGP_DBA2J_G0018187	protein coding gene	Chr11:55520287-55533794 (+)
FVB/NJ	MGP_FVBNJ_G0018178	protein coding gene	Chr11:55208195-55220145 (+)
LP/J	MGP_LPJ_G0018262	protein coding gene	Chr11:58628624-58641021 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018204	protein coding gene	Chr11:63732162-63744150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018786	protein coding gene	Chr11:57762102-57773564 (+)
PWK/PhJ	MGP_PWKPhJ_G0017440	protein coding gene	Chr11:56133680-56151819 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017235	protein coding gene	Chr11:57641979-57657371 (+)
WSB/EiJ	MGP_WSBEiJ_G0017715	protein coding gene	Chr11:57399752-57414877 (+)

Homology

• Human Ortholog
  LYPD8, LY6/PLAUR domain containing 8

• Vertebrate Orthologs
  9

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LYPD8, LY6/PLAUR domain containing 8
  
• Links
  HGNC:44208

  NCBI Gene ID: 646627

  neXtProt AC: NX_Q6UX82

  UniProt: Q6UX82

  
  
• Chr Location
  1q44; chr1:248739415-248755759 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lypd8 stringent orthology
  1 human;1 mouse;1 rat;7 zebrafish
  
• HCOP
  vertebrate homology predictions: LYPD8
• Gene Tree
  Lypd8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 2 alleles in 2 genetic backgrounds
  9 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  1 involving Lypd8
• Incidental Mutations
  APF
• Find Mice (IMSR)
  22 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit invasion of the colonic epithelia by intestinal flagellated bacteria and increased susceptibility to DSS-induced colitis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  4

Expression

• Assay Results
  719
• Tissues
  1
• cDNA Data
  288
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  6
• UniProt
  2
• CCDS
  CCDS36163.1

• Ensembl
  ENSMUSG00000013643 (Evidence)
• NCBI Gene
  70163

Representative Sequences			Length	Strain/Species
genomic	70163	NCBI Gene Model | MGI Sequence Detail	11497	C57BL/6J
transcript	NM_001083884	RefSeq | MGI Sequence Detail	1095	C57BL/6
polypeptide	Q9D7S0	UniProt | EBI | MGI Sequence Detail	255	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000031425 Ly6/PLAUR domain-containing protein 8
  (term hierarchy)
• InterPro Domains
  IPR050918 CNF-like Phospholipase A2 Inhibitor
  IPR016054 Ly-6 antigen/uPA receptor-like
  IPR045860 Snake toxin-like superfamily
• GlyGen
  Q9D7S0 13 sites

Molecular
Reagents

• All nucleic 288

  cDNA 288

  
  

  Microarray probesets 3

References

• Summaries
  All 35

  Developmental Gene Expression 2

  Gene Ontology 4

  Phenotypes 9
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94

TSS for Lypd8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101723	Chr11:58268367-58268372 (+)	-1,499 bp
Tssr101724	Chr11:58269862-58269878 (+)	1 bp
Tssr101725	Chr11:58270462-58270502 (+)	613 bp
Tssr101726	Chr11:58271367-58271378 (+)	1,504 bp
Tssr101727	Chr11:58271387-58271445 (+)	1,547 bp
Tssr101728	Chr11:58271446-58271463 (+)	1,586 bp
Tssr101729	Chr11:58273106-58273125 (+)	3,247 bp
Tssr101730	Chr11:58273136-58273151 (+)	3,275 bp
Tssr101731	Chr11:58273159-58273174 (+)	3,298 bp
Tssr101732	Chr11:58273572-58273615 (+)	3,725 bp
Tssr101733	Chr11:58273622-58273640 (+)	3,762 bp
Tssr101734	Chr11:58273663-58273672 (+)	3,799 bp
Tssr101735	Chr11:58275433-58275446 (+)	5,571 bp
Tssr101736	Chr11:58275494-58275514 (+)	5,635 bp
Tssr101737	Chr11:58275545-58275554 (+)	5,681 bp
Tssr101738	Chr11:58275566-58275572 (+)	5,700 bp
Tssr101739	Chr11:58277549-58277587 (+)	7,699 bp
Tssr101740	Chr11:58277613-58277632 (+)	7,754 bp
Tssr101741	Chr11:58277641-58277650 (+)	7,777 bp
Tssr101742	Chr11:58280914-58280961 (+)	11,069 bp
Tssr101743	Chr11:58280983-58281060 (+)	11,153 bp
Tssr101744	Chr11:58281065-58281076 (+)	11,202 bp
Tssr101745	Chr11:58281094-58281117 (+)	11,237 bp