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Med23 Gene Detail
Summary
  • Symbol
    Med23
  • Name
    mediator complex subunit 23
  • Synonyms
    3000002A17Rik, Crsp3, ESTM7, mKIAA1216, sno, Sur2, X83317
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917458
    NCBI Gene: 70208
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24745889-24789358 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1292 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917458
 protein coding gene Chr10:24745884-24789579 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017095
 protein coding gene Chr10:22866436-22911660 (+)
A/J MGP_AJ_G0017072
 protein coding gene Chr10:22191497-22235229 (+)
AKR/J MGP_AKRJ_G0017032
 protein coding gene Chr10:22566704-22611062 (+)
BALB/cJ MGP_BALBcJ_G0017035
 protein coding gene Chr10:22287096-22333100 (+)
C3H/HeJ MGP_C3HHeJ_G0016855
 protein coding gene Chr10:22774453-22819546 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017493
 protein coding gene Chr10:23571563-23616244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015191
 protein coding gene Chr10:20880587-20927121 (+)
CAST/EiJ MGP_CASTEiJ_G0016434
 protein coding gene Chr10:22704278-22752554 (+)
CBA/J MGP_CBAJ_G0016829
 protein coding gene Chr10:24643431-24688967 (+)
DBA/2J MGP_DBA2J_G0016934
 protein coding gene Chr10:21922167-21965693 (+)
FVB/NJ MGP_FVBNJ_G0016929
 protein coding gene Chr10:21620503-21665433 (+)
LP/J MGP_LPJ_G0017011
 protein coding gene Chr10:22850452-22904494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016959
 protein coding gene Chr10:24752785-24797890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017529
 protein coding gene Chr10:22419755-22463625 (+)
PWK/PhJ MGP_PWKPhJ_G0016216
 protein coding gene Chr10:21708428-21753178 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016000
 protein coding gene Chr10:22246277-22299546 (+)
WSB/EiJ MGP_WSBEiJ_G0016497
 protein coding gene Chr10:22547713-22596024 (+)



Homology
more
  • Human Ortholog
    MED23, mediator complex subunit 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED23, mediator complex subunit 23
  • Synonyms
    ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2
  • Links
    NCBI Gene ID: 9439
    neXtProt AC: NX_Q9ULK4
    UniProt: Q9ULK4

  • Chr Location
    6q23.2; chr6:131573966-131628313 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MED23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 6 alleles in 6 genetic backgrounds
    4 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis with disorganization of the vasculature and peripheral nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    21
  • cDNA Data
    131
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70208 NCBI Gene Model | MGI Sequence Detail 43470 C57BL/6J ±  kb
    transcript NM_001166416 RefSeq | MGI Sequence Detail 4825 ZRU/MplStud  
    polypeptide Q80YQ2 UniProt | EBI | MGI Sequence Detail 1367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 131
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28117, MGI:104823, MGI:5004966
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:349816 Fang Y, et al., The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration. Cell Rep. 2024 May 28;43(5):114177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory