Krt78 MGI Mouse Gene Detail - MGI:1917529

Symbol

Krt78
Name

keratin 78
Synonyms

2310030B04Rik

Feature Type

protein coding gene
IDs

MGI:1917529
NCBI Gene: 332131
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:101854436-101862722 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.15 cM
Mapping Data

1 experiment

SNPs within 2kb

387 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917529	protein coding gene	Chr15:101854436-101905059 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022394	protein coding gene	Chr15:104079005-104086881 (-)
A/J	no annotation
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0022360	protein coding gene	Chr15:100046105-100054116 (-)
C3H/HeJ	MGP_C3HHeJ_G0022127	protein coding gene	Chr15:103088478-103098393 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022809	protein coding gene	Chr15:107948628-107956506 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020332	protein coding gene	Chr15:95782542-95790566 (-)
CAST/EiJ	MGP_CASTEiJ_G0021653	protein coding gene	Chr15:103947967-103955408 (-)
CBA/J	MGP_CBAJ_G0022096	protein coding gene	Chr15:111711671-111720654 (-)
DBA/2J	MGP_DBA2J_G0022227	protein coding gene	Chr15:99285904-99294054 (-)
FVB/NJ	MGP_FVBNJ_G0022203	protein coding gene	Chr15:98343864-98351611 (-)
LP/J	MGP_LPJ_G0022296	protein coding gene	Chr15:104234764-104244224 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022225	protein coding gene	Chr15:115328704-115336452 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022821	protein coding gene	Chr15:103047740-103055977 (-)
PWK/PhJ	MGP_PWKPhJ_G0021393	protein coding gene	Chr15:99434308-99442228 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021225	protein coding gene	Chr15:102881138-102889023 (-)
WSB/EiJ	MGP_WSBEiJ_G0021703	protein coding gene	Chr15:103672431-103680848 (-)

Human Ortholog

KRT78, keratin 78

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT78, keratin 78
Synonyms

CK-78, K5B, K78, Kb40
Links

HGNC:28926

NCBI Gene ID: 196374

neXtProt AC: NX_Q8N1N4

UniProt: Q8N1N4
Chr Location

12q13.13; chr12:52837804-52849092 (-) GRCh38

MGI Vertebrate Homology

Krt78 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT78
Gene Tree

Krt78

less

References

1 with disease annotations

less

Phenotype Summary

30 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

4 involving Krt78
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

less

All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase krt78, krt78.2, krt78.5, krt78.6, krt78.7, krt78.9

less

All Sequences

42
RefSeq

6
UniProt

6
CCDS

CCDS49736.1

Ensembl

ENSMUSG00000050463 (Evidence)
NCBI Gene

332131

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050463	Ensembl Gene Model \| MGI Sequence Detail	8287	C57BL/6J	± kb
transcript	ENSMUST00000164932	Ensembl \| MGI Sequence Detail	3437	Not Applicable
polypeptide	ENSMUSP00000126197	Ensembl \| MGI Sequence Detail	1068	Not Applicable

less

UniProt

6 Sequences
InterPro Domains

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head
GlyGen

E9Q0F0 1 site, 1 O-linked glycan (1 site)

less

All nucleic 7

cDNA 7

Microarray probesets 2

Summaries

All 46

Diseases 1

Gene Ontology 2

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Krt78:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136646	Chr15:101862711-101862729 (-)	2 bp
Tssr136645	Chr15:101862684-101862700 (-)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24