Rnf126 MGI Mouse Gene Detail - MGI:1917544

Symbol

Rnf126
Name

ring finger protein 126
Synonyms

2610010O19Rik

Feature Type

protein coding gene
IDs

MGI:1917544
NCBI Gene: 70294
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:79594349-79602786 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917544	protein coding gene	Chr10:79594349-79607282 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017458	protein coding gene	Chr10:80300590-80309954 (-)
A/J	MGP_AJ_G0017436	protein coding gene	Chr10:77512171-77520600 (-)
AKR/J	MGP_AKRJ_G0017397	protein coding gene	Chr10:79619570-79628005 (-)
BALB/cJ	MGP_BALBcJ_G0017398	protein coding gene	Chr10:77737869-77746292 (-)
C3H/HeJ	MGP_C3HHeJ_G0017221	protein coding gene	Chr10:79727332-79735787 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017852	protein coding gene	Chr10:83075661-83084099 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015540	protein coding gene	Chr10:73736854-73745343 (-)
CAST/EiJ	MGP_CASTEiJ_G0016788	protein coding gene	Chr10:79899612-79908017 (-)
CBA/J	MGP_CBAJ_G0017193	protein coding gene	Chr10:86299616-86308030 (-)
DBA/2J	MGP_DBA2J_G0017299	protein coding gene	Chr10:76726908-76735327 (-)
FVB/NJ	MGP_FVBNJ_G0017293	protein coding gene	Chr10:75893487-75902008 (-)
LP/J	MGP_LPJ_G0017370	protein coding gene	Chr10:80783128-80791566 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017319	protein coding gene	Chr10:88279535-88288000 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017893	protein coding gene	Chr10:79595073-79604720 (-)
PWK/PhJ	MGP_PWKPhJ_G0016569	protein coding gene	Chr10:76585654-76594043 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016358	protein coding gene	Chr10:78571547-78580101 (-)
WSB/EiJ	MGP_WSBEiJ_G0016848	protein coding gene	Chr10:79626812-79635239 (-)

Human Ortholog

RNF126, ring finger protein 126

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF126, ring finger protein 126
Links

HGNC:21151

NCBI Gene ID: 55658

neXtProt AC: NX_Q9BV68

UniProt: Q9BV68
Chr Location

19p13.3; chr19:647526-663233 (-) GRCh38

MGI Vertebrate Homology

Rnf126 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF126
Gene Tree

Rnf126

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Targeted

7
Genomic Mutations

1 involving Rnf126
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show partial prenatal lethality and shorter survival time and increased cellular apoptosis following irradiation exposure.

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All GO Annotations

42
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

81

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf126

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All Sequences

50
RefSeq

9
UniProt

2
CCDS

CCDS23989.1

Ensembl

ENSMUSG00000035890 (Evidence)
NCBI Gene

70294

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035890	Ensembl Gene Model \| MGI Sequence Detail	8438	C57BL/6J	± kb
transcript	ENSMUST00000047203	Ensembl \| MGI Sequence Detail	1639	Not Applicable
polypeptide	ENSMUSP00000039486	Ensembl \| MGI Sequence Detail	313	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014078 E3 ubiquitin-protein ligase RNF126

(term hierarchy)
PDB

2ECT
EC

2.3.2.27
InterPro Domains

IPR039525 E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon

IPR039571 RNF126, RING finger, H2 subclass

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q91YL2 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 81

cDNA 81

Microarray probesets 4

Summaries

All 45

Gene Ontology 6

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf126:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98350	Chr10:79602828-79602851 (-)	-54 bp
Tssr98349	Chr10:79602791-79602810 (-)	-15 bp
Tssr98348	Chr10:79602706-79602784 (-)	41 bp
Tssr98347	Chr10:79602645-79602659 (-)	134 bp
Tssr98346	Chr10:79602626-79602637 (-)	154 bp
Tssr98345	Chr10:79598343-79598370 (-)	4,429 bp
Tssr98344	Chr10:79597329-79597330 (-)	5,456 bp
Tssr98343	Chr10:79596884-79596919 (-)	5,884 bp
Tssr98342	Chr10:79595010-79595061 (-)	7,750 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24