Gcc2 MGI Mouse Gene Detail - MGI:1917547 - GRIP and coiled-coil domain containing 2

Symbol

Gcc2
Name

GRIP and coiled-coil domain containing 2
Synonyms

0610043A03Rik, 2210420P05Rik, 2600014C01Rik, mKIAA0336

Feature Type

protein coding gene
IDs

MGI:1917547
NCBI Gene: 70297
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:58091319-58141421 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.30 cM, cytoband B3
Mapping Data

4 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917547	protein coding gene	Chr10:58091240-58141421 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017245	protein coding gene	Chr10:57340877-57394996 (+)
A/J	MGP_AJ_G0017222	protein coding gene	Chr10:55690772-55740909 (+)
AKR/J	MGP_AKRJ_G0017181	protein coding gene	Chr10:57145169-57193716 (+)
BALB/cJ	MGP_BALBcJ_G0017183	protein coding gene	Chr10:55772175-55821905 (+)
C3H/HeJ	MGP_C3HHeJ_G0017006	protein coding gene	Chr10:57054893-57106666 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017641	protein coding gene	Chr10:59439606-59491169 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015332	protein coding gene	Chr10:52805826-52860380 (+)
CAST/EiJ	MGP_CASTEiJ_G0016577	protein coding gene	Chr10:56971913-57019235 (+)
CBA/J	MGP_CBAJ_G0016978	protein coding gene	Chr10:61563299-61618961 (+)
DBA/2J	MGP_DBA2J_G0017083	protein coding gene	Chr10:55018972-55068254 (+)
FVB/NJ	MGP_FVBNJ_G0017077	protein coding gene	Chr10:54252129-54301447 (+)
LP/J	MGP_LPJ_G0017158	protein coding gene	Chr10:57736699-57788083 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017105	protein coding gene	Chr10:64114611-64176034 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017678	protein coding gene	Chr10:56944270-56994657 (+)
PWK/PhJ	MGP_PWKPhJ_G0016360	protein coding gene	Chr10:54797913-54850030 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016145	protein coding gene	Chr10:56313402-56361162 (+)
WSB/EiJ	MGP_WSBEiJ_G0016641	protein coding gene	Chr10:56848335-56903148 (+)

Human Ortholog

GCC2, GRIP and coiled-coil domain containing 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GCC2, GRIP and coiled-coil domain containing 2
Synonyms

GCC185, RANBP2L4, REN53
Links

HGNC:23218

NCBI Gene ID: 9648

neXtProt AC: NX_Q8IWJ2

UniProt: Q8IWJ2
Chr Location

2q12.3; chr2:108449107-108509415 (+) GRCh38

MGI Vertebrate Homology

Gcc2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GCC2
Gene Tree

Gcc2

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Genomic Mutations

2 involving Gcc2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for a null allele display elevated IgM autoantibodies.

less

All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

84

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gcc2

less

All Sequences

67
RefSeq

5
UniProt

8
CCDS

CCDS23859.1

Ensembl

ENSMUSG00000038039 (Evidence)
NCBI Gene

70297

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038039	Ensembl Gene Model \| MGI Sequence Detail	50103	C57BL/6J	± kb
transcript	ENSMUST00000057659	Ensembl \| MGI Sequence Detail	6547	Not Applicable
polypeptide	ENSMUSP00000054033	Ensembl \| MGI Sequence Detail	1680	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000007887 GRIP and coiled-coil domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR032023 GCC2, Rab binding domain

IPR000237 GRIP domain

IPR051841 Microtubule and Golgi organization protein
GlyGen

Q8CHG3 1 site, 1 N-linked glycan (1 site)

less

All nucleic 85

cDNA 85

Microarray probesets 4

less

MGI:1917423, MGI:1923516, MGI:2143810

Summaries

All 42

Gene Ontology 7

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346915 Tu X, et al., Interruption of post-Golgi STING trafficking activates tonic interferon signaling. Nat Commun. 2022 Nov 15;13(1):6977

TSS for Gcc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93422	Chr10:58091287-58091359 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24