Cactin MGI Mouse Gene Detail - MGI:1917562 - cactin, spliceosome C complex subunit

Symbol

Cactin
Name

cactin, spliceosome C complex subunit
Synonyms

2510012J08Rik

Feature Type

protein coding gene
IDs

MGI:1917562
NCBI Gene: 70312
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:81156937-81162076 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917562	protein coding gene	Chr10:81156937-81162085 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017550	protein coding gene	Chr10:82033495-82038643 (+)
A/J	MGP_AJ_G0017528	protein coding gene	Chr10:79124728-79129876 (+)
AKR/J	MGP_AKRJ_G0017489	protein coding gene	Chr10:81298243-81303391 (+)
BALB/cJ	MGP_BALBcJ_G0017490	protein coding gene	Chr10:79344343-79349491 (+)
C3H/HeJ	MGP_C3HHeJ_G0017313	protein coding gene	Chr10:81398170-81403318 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017944	protein coding gene	Chr10:84847107-84852255 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015633	protein coding gene	Chr10:75321577-75326737 (+)
CAST/EiJ	MGP_CASTEiJ_G0016880	protein coding gene	Chr10:81626022-81631172 (+)
CBA/J	MGP_CBAJ_G0017285	protein coding gene	Chr10:88157179-88162327 (+)
DBA/2J	MGP_DBA2J_G0017391	protein coding gene	Chr10:78329637-78334785 (+)
FVB/NJ	MGP_FVBNJ_G0017385	protein coding gene	Chr10:77577147-77582295 (+)
LP/J	MGP_LPJ_G0017462	protein coding gene	Chr10:82480708-82485856 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017411	protein coding gene	Chr10:90003640-90008788 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017985	protein coding gene	Chr10:81307860-81313008 (+)
PWK/PhJ	MGP_PWKPhJ_G0016661	protein coding gene	Chr10:78222744-78227892 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016451	protein coding gene	Chr10:80250185-80255312 (+)
WSB/EiJ	MGP_WSBEiJ_G0016940	protein coding gene	Chr10:81335185-81340333 (+)

Human Ortholog

CACTIN, cactin, spliceosome C complex subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CACTIN, cactin, spliceosome C complex subunit
Synonyms

C19orf29, fSAPc, NY-REN-24
Links

HGNC:29938

NCBI Gene ID: 58509

neXtProt AC: NX_Q8WUQ7

UniProt: Q8WUQ7
Chr Location

19p13.3; chr19:3610645-3626815 (-) GRCh38

MGI Vertebrate Homology

Cactin stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CACTIN
Gene Tree

Cactin

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Cactin
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

40
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

56

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cactin

ZFIN cactin

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS35995.1

Ensembl

ENSMUSG00000034889 (Evidence)
NCBI Gene

70312

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034889	Ensembl Gene Model \| MGI Sequence Detail	5140	C57BL/6J	± kb
transcript	ENSMUST00000050867	Ensembl \| MGI Sequence Detail	2715	Not Applicable
polypeptide	ENSMUSP00000059533	Ensembl \| MGI Sequence Detail	772	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031859 splicing factor Cactin

(term hierarchy)
InterPro Domains

IPR018816 Splicing factor cactin, central domain

IPR019134 Splicing factor Cactin, C-terminal

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All nucleic 56

cDNA 56

Microarray probesets 2

Summaries

All 34

Gene Ontology 6

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cactin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94735	Chr10:81155336-81155374 (+)	-1,582 bp
Tssr94736	Chr10:81155523-81155561 (+)	-1,395 bp
Tssr94737	Chr10:81157021-81157081 (+)	114 bp
Tssr94738	Chr10:81157089-81157104 (+)	160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24