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Hdac8 Gene Detail
Summary
  • Symbol
    Hdac8
  • Name
    histone deacetylase 8
  • Synonyms
    2610007D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917565
    NCBI Gene: 70315
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101328245-101548965 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 45.28 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917565
 protein coding gene ChrX:101328244-101549005 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035973
 protein coding gene ChrX:98874232-99104261 (-)
A/J MGP_AJ_G0035958
 protein coding gene ChrX:98832825-99061606 (-)
AKR/J MGP_AKRJ_G0035873
 protein coding gene ChrX:101700969-101934105 (-)
BALB/cJ MGP_BALBcJ_G0035943
 protein coding gene ChrX:97570411-97779060 (-)
C3H/HeJ MGP_C3HHeJ_G0035651
 protein coding gene ChrX:99250246-99474876 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036471
 protein coding gene ChrX:101804977-102021603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033300
 protein coding gene ChrX:96531421-96781226 (-)
CAST/EiJ MGP_CASTEiJ_G0034937
 protein coding gene ChrX:83570062-83792138 (-)
CBA/J MGP_CBAJ_G0035625
 protein coding gene ChrX:104974869-105210079 (-)
DBA/2J MGP_DBA2J_G0035779
 protein coding gene ChrX:98043465-98263034 (-)
FVB/NJ MGP_FVBNJ_G0035718
 protein coding gene ChrX:97410077-97630942 (-)
LP/J MGP_LPJ_G0035871
 protein coding gene ChrX:99791420-100014010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035752
 protein coding gene ChrX:109481297-109704212 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036497
 protein coding gene ChrX:98537133-98768181 (-)
PWK/PhJ MGP_PWKPhJ_G0034636
 protein coding gene ChrX:81135954-81364142 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034464
 protein coding gene ChrX:84478499-84699928 (-)
WSB/EiJ MGP_WSBEiJ_G0035076
 protein coding gene ChrX:97229001-97446900 (-)



Homology
more
  • Human Ortholog
    HDAC8, histone deacetylase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC8, histone deacetylase 8
  • Synonyms
    CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6, RPD3, WTS
  • Links
    NCBI Gene ID: 55869
    neXtProt AC: NX_Q9BY41
    UniProt: Q9BY41

  • Chr Location
    Xq13.1; chrX:72329516-72573101 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hdac8 mouse models; 2 with human HDAC8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous or homozygous for the null allele exhibit background sensitive defects in frontal and interparietal bone ossification. On a C57BL/6 background the phenotype is severe leading to death within 4-6 hours of birth from brain hemorrhaging.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    33
  • cDNA Data
    15
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067567 Ensembl Gene Model | MGI Sequence Detail 220721 C57BL/6J ±  kb
    transcript ENSMUST00000087916 Ensembl | MGI Sequence Detail 1936 Not Applicable  
    polypeptide ENSMUSP00000085226 Ensembl | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347015 Fukuda M, et al., Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone. Int J Mol Sci. 2024 Feb 22;25(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory