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Ica1l Gene Detail
Summary
  • Symbol
    Ica1l
  • Name
    islet cell autoantigen 1-like
  • Synonyms
    1700030B17Rik, Als2cr15, b2b3465Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917625
    NCBI Gene: 70375
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:60024955-60082646 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 30.45 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1735 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917625
 protein coding gene Chr1:60021649-60082646 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016072
 protein coding gene Chr1:60010503-60078461 (-)
A/J MGP_AJ_G0016055
 protein coding gene Chr1:57896667-57959663 (-)
AKR/J MGP_AKRJ_G0016011
 protein coding gene Chr1:59523380-59588383 (-)
BALB/cJ MGP_BALBcJ_G0016010
 protein coding gene Chr1:57924768-57984292 (-)
C3H/HeJ MGP_C3HHeJ_G0015842
 protein coding gene Chr1:59773645-59837482 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016463
 protein coding gene Chr1:62349656-62414929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014184
 protein coding gene Chr1:54101624-54165916 (-)
CAST/EiJ MGP_CASTEiJ_G0015424
 protein coding gene Chr1:58957821-59025149 (-)
CBA/J MGP_CBAJ_G0015814
 protein coding gene Chr1:64291834-64361285 (-)
DBA/2J MGP_DBA2J_G0015915
 protein coding gene Chr1:57321201-57385422 (-)
FVB/NJ MGP_FVBNJ_G0015917
 protein coding gene Chr1:56622951-56684223 (-)
LP/J MGP_LPJ_G0015987
 protein coding gene Chr1:60894217-60957748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015937
 protein coding gene Chr1:67210059-67277586 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016510
 protein coding gene Chr1:59427684-59500895 (-)
PWK/PhJ MGP_PWKPhJ_G0015211
 protein coding gene Chr1:56671746-56735152 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014991
 protein coding gene Chr1:58962014-59023894 (-)
WSB/EiJ MGP_WSBEiJ_G0015487
 protein coding gene Chr1:59136376-59202802 (-)



Homology
more
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
  • Synonyms
    ALS2CR14, ALS2CR15
  • Links
    NCBI Gene ID: 130026
    neXtProt AC: NX_Q8NDH6
    UniProt: Q8NDH6

  • Chr Location
    2q33.2; chr2:202773150-202871766 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    21 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit reduced male fertility with oligospermia, globospermia, and abnormal spermiogenesis, sperm nucleus and mitochondrial sheath morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70375 NCBI Gene Model | MGI Sequence Detail 57692 C57BL/6J ±  kb
    transcript NM_027407 RefSeq | MGI Sequence Detail 3727 C57BL/6  
    polypeptide Q3TY65 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5648232
    References
    more
    • Summaries
      All 39
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory