Csnk1g3 MGI Mouse Gene Detail - MGI:1917675

Symbol

Csnk1g3
Name

casein kinase 1, gamma 3
Synonyms

3300002K07Rik, C330049O21Rik

Feature Type

protein coding gene
IDs

MGI:1917675
NCBI Gene: 70425
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:53995194-54088620 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 29.10 cM
Mapping Data

2 experiments

SNPs within 2kb

1799 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917675	protein coding gene	Chr18:53995154-54088756 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024438	protein coding gene	Chr18:53059303-53156965 (+)
A/J	MGP_AJ_G0024404	protein coding gene	Chr18:51000806-51088221 (+)
AKR/J	MGP_AKRJ_G0024374	protein coding gene	Chr18:52416330-52503665 (+)
BALB/cJ	MGP_BALBcJ_G0024404	protein coding gene	Chr18:51179816-51273187 (+)
C3H/HeJ	MGP_C3HHeJ_G0024171	protein coding gene	Chr18:52561004-52651480 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024850	protein coding gene	Chr18:54820830-54916484 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022282	protein coding gene	Chr18:50757083-50841268 (+)
CAST/EiJ	MGP_CASTEiJ_G0023645	protein coding gene	Chr18:52564238-52657359 (+)
CBA/J	MGP_CBAJ_G0024141	protein coding gene	Chr18:56450156-56559855 (+)
DBA/2J	MGP_DBA2J_G0024271	protein coding gene	Chr18:50709875-50797944 (+)
FVB/NJ	MGP_FVBNJ_G0024238	protein coding gene	Chr18:50131574-50219626 (+)
LP/J	MGP_LPJ_G0024356	protein coding gene	Chr18:53070560-53166386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024268	protein coding gene	Chr18:58197611-58308913 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024897	protein coding gene	Chr18:52461929-52551144 (+)
PWK/PhJ	MGP_PWKPhJ_G0023389	protein coding gene	Chr18:50721702-50810804 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023195	protein coding gene	Chr18:52625945-52711705 (+)
WSB/EiJ	MGP_WSBEiJ_G0023708	protein coding gene	Chr18:52387684-52494178 (+)

Human Ortholog

CSNK1G3, casein kinase 1 gamma 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSNK1G3, casein kinase 1 gamma 3
Synonyms

CKI-gamma 3, CSNK1G3L
Links

HGNC:2456

NCBI Gene ID: 1456

neXtProt AC: NX_Q9Y6M4

UniProt: Q9Y6M4
Chr Location

5q23.2; chr5:123512177-123617049 (+) GRCh38

MGI Vertebrate Homology

Csnk1g3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CSNK1G3
Gene Tree

Csnk1g3

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

4
Gene trapped

18
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Csnk1g3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

32
cDNA Data

21
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csnk1g3

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All Sequences

71
RefSeq

18
UniProt

3
CCDS

CCDS37823.1

Ensembl

ENSMUSG00000073563 (Evidence)
NCBI Gene

70425

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073563	Ensembl Gene Model \| MGI Sequence Detail	93427	C57BL/6J	± kb
transcript	ENSMUST00000237880	Ensembl \| MGI Sequence Detail	2180	Not Applicable
polypeptide	ENSMUSP00000158175	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005949 casein kinase I isoform gamma-3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR022247 Casein kinase 1 gamma C-terminal

IPR050235 Casein Kinase 1 Ser/Thr Protein Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q8C4X2 1 site, 1 N-linked glycan (1 site)

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 7

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MGI:2444154

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Csnk1g3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151102	Chr18:53995159-53995215 (+)	-7 bp
Tssr151103	Chr18:53995301-53995391 (+)	152 bp
Tssr151104	Chr18:53995392-53995413 (+)	209 bp
Tssr5320	Chr18:53995464-53995475 (+)	276 bp
Tssr151105	Chr18:54010796-54010828 (+)	15,618 bp
Tssr151106	Chr18:54022206-54022219 (+)	27,019 bp
Tssr151107	Chr18:54055163-54055179 (+)	59,977 bp
Tssr151108	Chr18:54070417-54070418 (+)	75,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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