Taf15 MGI Mouse Gene Detail - MGI:1917689 - TATA-box binding protein associated factor 15

Symbol

Taf15
Name

TATA-box binding protein associated factor 15
Synonyms

2610111C21Rik, 68kDa, Taf2n, TAFII68

Feature Type

protein coding gene
IDs

MGI:1917689
NCBI Gene: 70439
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:83363912-83397569 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.49 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

558 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917689	protein coding gene	Chr11:83363897-83397569 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018850	protein coding gene	Chr11:84796648-84839017 (+)
A/J	MGP_AJ_G0018817	protein coding gene	Chr11:81583465-81616888 (+)
AKR/J	MGP_AKRJ_G0018787	protein coding gene	Chr11:84008517-84057530 (+)
BALB/cJ	MGP_BALBcJ_G0018790	protein coding gene	Chr11:81994262-82027289 (+)
C3H/HeJ	MGP_C3HHeJ_G0018604	protein coding gene	Chr11:84068394-84103387 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019242	protein coding gene	Chr11:87394328-87432947 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016876	protein coding gene	Chr11:78710134-78745513 (+)
CAST/EiJ	MGP_CASTEiJ_G0018159	protein coding gene	Chr11:84644173-84688451 (+)
CBA/J	MGP_CBAJ_G0018575	protein coding gene	Chr11:91176773-91212570 (+)
DBA/2J	MGP_DBA2J_G0018683	protein coding gene	Chr11:81179728-81217304 (+)
FVB/NJ	MGP_FVBNJ_G0018672	protein coding gene	Chr11:80662481-80700793 (+)
LP/J	MGP_LPJ_G0018753	protein coding gene	Chr11:85360422-85397047 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0019282	protein coding gene	Chr11:84281205-84320396 (+)
PWK/PhJ	MGP_PWKPhJ_G0017928	protein coding gene	Chr11:81940933-81975497 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017720	protein coding gene	Chr11:83818791-83856346 (+)
WSB/EiJ	MGP_WSBEiJ_G0018210	protein coding gene	Chr11:84144106-84181984 (+)

Human Ortholog

TAF15, TATA-box binding protein associated factor 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF15, TATA-box binding protein associated factor 15
Synonyms

Npl3, RBP56, TAF2N, TAFII68
Links

HGNC:11547

NCBI Gene ID: 8148

neXtProt AC: NX_Q92804

UniProt: Q92804
Chr Location

17q12; chr17:35809482-35864615 (+) GRCh38

MGI Vertebrate Homology

Taf15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF15
Gene Tree

Taf15

Diseases

2 with human TAF15 associations

				Human Disease	Mouse Models
				chondrosarcoma IDs chondrosarcoma DOID:3371 DOID:3370 MESH:D002813 NCI:C2946 NCI:C7155 OMIM:215300 UMLS_CUI:C0008479 UMLS_CUI:C1335473
				extraskeletal myxoid chondrosarcoma IDs extraskeletal myxoid chondrosarcoma DOID:4549 MESH:C563195 NCI:C27502 OMIM:612237 UMLS_CUI:C1275278

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

22
Targeted

3
Genomic Mutations

2 involving Taf15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

55
cDNA Data

36
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TAF15

Xenbase taf15

ZFIN taf15

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All Sequences

57
RefSeq

16
UniProt

4
CCDS

CCDS25168.1

Ensembl

ENSMUSG00000020680 (Evidence)
NCBI Gene

70439

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020680	Ensembl Gene Model \| MGI Sequence Detail	33658	C57BL/6J	± kb
transcript	ENSMUST00000021018	Ensembl \| MGI Sequence Detail	2068	Not Applicable
polypeptide	ENSMUSP00000021018	Ensembl \| MGI Sequence Detail	557	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034870 TAF15/EWS/TLS family

IPR001876 Zinc finger, RanBP2-type

IPR036443 Zinc finger, RanBP2-type superfamily

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All nucleic 40

Genomic 1

cDNA 38

Primer pair 1

Microarray probesets 4

Summaries

All 53

Developmental Gene Expression 8

Gene Ontology 3

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Taf15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103703	Chr11:83363905-83363949 (+)	15 bp
Tssr103704	Chr11:83363966-83363983 (+)	63 bp
Tssr103705	Chr11:83381434-83381438 (+)	17,524 bp
Tssr103706	Chr11:83390934-83390943 (+)	27,027 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24