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Mpc2 Gene Detail
Summary
  • Symbol
    Mpc2
  • Name
    mitochondrial pyruvate carrier 2
  • Synonyms
    0610006C01Rik, 2010002I07Rik, 2610205H19Rik, Brp44, ESTM43
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917706
    NCBI Gene: 70456
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165288829-165308787 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 72.80 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917706
 protein coding gene Chr1:165288206-165308787 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016693
 protein coding gene Chr1:170947136-170975208 (+)
A/J MGP_AJ_G0016674
 protein coding gene Chr1:163970620-163991647 (+)
AKR/J MGP_AKRJ_G0016640
 protein coding gene Chr1:168932067-168952597 (+)
BALB/cJ MGP_BALBcJ_G0016635
 protein coding gene Chr1:164466106-164486965 (+)
C3H/HeJ MGP_C3HHeJ_G0016459
 protein coding gene Chr1:169152054-169173351 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017096
 protein coding gene Chr1:176680316-176701976 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014805
 protein coding gene Chr1:155870041-155890472 (+)
CAST/EiJ MGP_CASTEiJ_G0016039
 protein coding gene Chr1:168769665-168794120 (+)
CBA/J MGP_CBAJ_G0016434
 protein coding gene Chr1:182955431-182982356 (+)
DBA/2J MGP_DBA2J_G0016540
 protein coding gene Chr1:162855019-162877892 (+)
FVB/NJ MGP_FVBNJ_G0016538
 protein coding gene Chr1:161294795-161318311 (+)
LP/J MGP_LPJ_G0016611
 protein coding gene Chr1:172004599-172024999 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016563
 protein coding gene Chr1:190458398-190480162 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017132
 protein coding gene Chr1:168792597-168813131 (+)
PWK/PhJ MGP_PWKPhJ_G0015825
 protein coding gene Chr1:162060298-162081170 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015612
 protein coding gene Chr1:167636977-167660611 (+)
WSB/EiJ MGP_WSBEiJ_G0016101
 protein coding gene Chr1:168947551-168968069 (+)



Homology
more
  • Human Ortholog
    MPC2, mitochondrial pyruvate carrier 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPC2, mitochondrial pyruvate carrier 2
  • Synonyms
    BRP44, SLC54A2
  • Links
    NCBI Gene ID: 25874
    neXtProt AC: NX_O95563
    UniProt: O95563

  • Chr Location
    1q24.2; chr1:167916675-167937072 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die during organogenesis. Mice homozygous for a truncated allele display defects in mitochondrial physiology and impaired glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    13
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70456 NCBI Gene Model | MGI Sequence Detail 19959 C57BL/6J ±  kb
    transcript NM_027430 RefSeq | MGI Sequence Detail 806 C57BL/6  
    polypeptide Q9D023 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004820 brain protein 44
      (term hierarchy)
    • InterPro Domains
      IPR005336 Mitochondrial pyruvate carrier
    • GlyGen
      Q9D023 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1334431, MGI:1915570, MGI:1919298
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:342356 Yiew NKH, et al., Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice. iScience. 2023 Nov 17;26(11):108196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory