Rprd1b MGI Mouse Gene Detail - MGI:1917720 - regulation of nuclear pre-mRNA domain containing 1B

Symbol

Rprd1b
Name

regulation of nuclear pre-mRNA domain containing 1B
Synonyms

2610304G08Rik, 2810446G03Rik, Crept

Feature Type

protein coding gene
IDs

MGI:1917720
NCBI Gene: 70470
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:157870395-157920127 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917720	protein coding gene	Chr2:157870395-157974217 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026788	protein coding gene	Chr2:163074654-163187858 (+)
A/J	MGP_AJ_G0026754	protein coding gene	Chr2:156543147-156651393 (+)
AKR/J	MGP_AKRJ_G0026725	protein coding gene	Chr2:161164652-161271618 (+)
BALB/cJ	MGP_BALBcJ_G0026763	protein coding gene	Chr2:156847771-156953160 (+)
C3H/HeJ	MGP_C3HHeJ_G0026505	protein coding gene	Chr2:161470821-161580724 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027212	protein coding gene	Chr2:167923006-168044767 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024582	protein coding gene	Chr2:149988418-150094863 (+)
CAST/EiJ	MGP_CASTEiJ_G0025967	protein coding gene	Chr2:161828095-161938575 (+)
CBA/J	MGP_CBAJ_G0026482	protein coding gene	Chr2:173956739-174079323 (+)
DBA/2J	MGP_DBA2J_G0026620	protein coding gene	Chr2:155719146-155824354 (+)
FVB/NJ	MGP_FVBNJ_G0026587	protein coding gene	Chr2:154119641-154227216 (+)
LP/J	MGP_LPJ_G0026723	protein coding gene	Chr2:163158814-163273509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026608	protein coding gene	Chr2:177778327-177891238 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027268	protein coding gene	Chr2:160970706-161084806 (+)
PWK/PhJ	MGP_PWKPhJ_G0025701	protein coding gene	Chr2:155236719-155342836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025504	protein coding gene	Chr2:159899301-160011719 (+)
WSB/EiJ	MGP_WSBEiJ_G0026037	protein coding gene	Chr2:161878085-161987457 (+)

Human Ortholog

RPRD1B, regulation of nuclear pre-mRNA domain containing 1B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPRD1B, regulation of nuclear pre-mRNA domain containing 1B
Synonyms

C20orf77, CREPT, dJ1057B20.2, K-H, Kub5-Hera, NET60
Links

HGNC:16209

NCBI Gene ID: 58490

neXtProt AC: NX_Q9NQG5

UniProt: Q9NQG5
Chr Location

20q11.23; chr20:38033725-38127780 (+) GRCh38

MGI Vertebrate Homology

Rprd1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPRD1B
Gene Tree

Rprd1b

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Gene trapped

12
Targeted

4
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in intestinal cells exhibit increased prenatal mortality, small body size, enlarged and thickened large intestine crypts, impaired proliferation and differentiation of Lgr5+ stem cells, and increased DSS-induced mortality.

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

31
cDNA Data

78
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rprd1b

ZFIN rprd1b

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All Sequences

78
RefSeq

18
UniProt

4
CCDS

CCDS16984.1, CCDS71176.1, CCDS71177.1

Ensembl

ENSMUSG00000027651 (Evidence)
NCBI Gene

70470

			Length	Strain/Species	Flank
genomic	70470	NCBI Gene Model \| MGI Sequence Detail	49733	C57BL/6J	± kb
transcript	NM_001291135	RefSeq \| MGI Sequence Detail	4616	C57BL/6
polypeptide	Q9CSU0	UniProt \| EBI \| MGI Sequence Detail	326	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031060 regulation of nuclear pre-mRNA domain-containing protein 1B

(term hierarchy)
InterPro Domains

IPR006569 CID domain

IPR008942 ENTH/VHS

IPR032337 RPRD1A/B, C-terminal domain

IPR047882 RPRD1B, CID domain

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All nucleic 80

cDNA 78

Primer pair 1

Other 1

Microarray probesets 7

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MGI:1920005

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rprd1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21296	Chr2:157870401-157870459 (+)	35 bp
Tssr21297	Chr2:157870467-157870488 (+)	83 bp
Tssr21298	Chr2:157870607-157870649 (+)	233 bp
Tssr21299	Chr2:157870653-157870741 (+)	302 bp
Tssr21300	Chr2:157910796-157910801 (+)	40,404 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24