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Bbx Gene Detail
Summary
  • Symbol
    Bbx
  • Name
    bobby sox HMG box containing
  • Synonyms
    5530401J07Rik, 5730403O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917758
    NCBI Gene: 70508
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:50012207-50252753 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 31.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6562 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917758
 protein coding gene Chr16:50012207-50252829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022875
 protein coding gene Chr16:49093518-49345816 (-)
A/J MGP_AJ_G0022842
 protein coding gene Chr16:46938227-47181962 (-)
AKR/J MGP_AKRJ_G0022814
 protein coding gene Chr16:48508822-48752123 (-)
BALB/cJ MGP_BALBcJ_G0022842
 protein coding gene Chr16:47021348-47262019 (-)
C3H/HeJ MGP_C3HHeJ_G0022605
 protein coding gene Chr16:48568303-48812608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023290
 protein coding gene Chr16:50345856-50601937 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020802
 protein coding gene Chr16:47000748-47243167 (-)
CAST/EiJ MGP_CASTEiJ_G0022131
 protein coding gene Chr16:48912808-49163381 (-)
CBA/J MGP_CBAJ_G0022578
 protein coding gene Chr16:52334737-52595042 (-)
DBA/2J MGP_DBA2J_G0022710
 protein coding gene Chr16:46675625-46917019 (-)
FVB/NJ MGP_FVBNJ_G0022685
 protein coding gene Chr16:46539867-46779547 (-)
LP/J MGP_LPJ_G0022777
 protein coding gene Chr16:48876256-49135353 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022703
 protein coding gene Chr16:52083599-52355870 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023305
 protein coding gene Chr16:48559476-48815575 (-)
PWK/PhJ MGP_PWKPhJ_G0021871
 protein coding gene Chr16:47018953-47263503 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021701
 protein coding gene Chr16:48389709-48641609 (-)
WSB/EiJ MGP_WSBEiJ_G0022176
 protein coding gene Chr16:48561764-48809064 (-)



Homology
more
  • Human Ortholog
    BBX, BBX high mobility group box domain containing
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BBX, BBX high mobility group box domain containing
  • Synonyms
    ARTC1, HBP2, HSPC339, MDS001
  • Links
    NCBI Gene ID: 56987
    neXtProt AC: NX_Q8WY36
    UniProt: Q8WY36

  • Chr Location
    3q13.12; chr3:107522936-107811339 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased IgA level, abnormal tooth morphology, and a reduction in heart weight, lean body mass, body length, long bone length, bone mineral density, and bone strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    80
  • cDNA Data
    106
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022641 Ensembl Gene Model | MGI Sequence Detail 240547 C57BL/6J ±  kb
    transcript ENSMUST00000138166 Ensembl | MGI Sequence Detail 8743 Not Applicable  
    polypeptide ENSMUSP00000119238 Ensembl | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004671 HMG box transcription factor BBX
      (term hierarchy)
    • PDB
      1WZ6
    • InterPro Domains
      IPR052412 Cell Cycle and Developmental Transcription Regulators
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR019102 HMG box transcription factor BBX, domain of unknown function DUF2028
      IPR049523 HMG box transcription factor BBX, HMG-box domain
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 106
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1921753
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory