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Qpct Gene Detail
Summary
  • Symbol
    Qpct
  • Name
    glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
  • Synonyms
    5730422A13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917786
    NCBI Gene: 70536
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:79359335-79397807 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 49.83 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1374 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917786
 protein coding gene Chr17:79359335-79397807 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024049
 protein coding gene Chr17:81891862-81932873 (+)
A/J MGP_AJ_G0024006
 protein coding gene Chr17:79385834-79422556 (+)
AKR/J MGP_AKRJ_G0023975
 protein coding gene Chr17:80590391-80626475 (+)
BALB/cJ MGP_BALBcJ_G0024008
 protein coding gene Chr17:79253986-79291196 (+)
C3H/HeJ MGP_C3HHeJ_G0023772
 protein coding gene Chr17:81495950-81534433 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024452
 protein coding gene Chr17:84883888-84922481 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021894
 protein coding gene Chr17:74786084-74823287 (+)
CAST/EiJ MGP_CASTEiJ_G0023252
 protein coding gene Chr17:82109025-82146535 (+)
CBA/J MGP_CBAJ_G0023746
 protein coding gene Chr17:88412575-88456027 (+)
DBA/2J MGP_DBA2J_G0023875
 protein coding gene Chr17:77902884-77939325 (+)
FVB/NJ MGP_FVBNJ_G0023841
 protein coding gene Chr17:77423638-77460393 (+)
LP/J MGP_LPJ_G0023958
 protein coding gene Chr17:82749173-82787718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023869
 protein coding gene Chr17:88530053-88568720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024497
 protein coding gene Chr17:81070305-81111619 (+)
PWK/PhJ MGP_PWKPhJ_G0022998
 protein coding gene Chr17:77401871-77447150 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022809
 protein coding gene Chr17:77854120-77891435 (+)
WSB/EiJ MGP_WSBEiJ_G0023319
 protein coding gene Chr17:81893134-81932042 (+)



Homology
more
  • Human Ortholog
    QPCT, glutaminyl-peptide cyclotransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QPCT, glutaminyl-peptide cyclotransferase
  • Synonyms
    GCT, QC, sQC
  • Links
    NCBI Gene ID: 25797
    neXtProt AC: NX_Q16769
    UniProt: Q16769

  • Chr Location
    2p22.2; chr2:37342827-37373322 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Mice exhibit normal motor coordination and spatial working memory. Mice homozygous for a different null allele exhibit normal monocyte number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    132
  • cDNA Data
    29
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70536 NCBI Gene Model | MGI Sequence Detail 38473 C57BL/6J ±  kb
transcript NM_027455 RefSeq | MGI Sequence Detail 2059 C57BL/6  
polypeptide Q9CYK2 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 29
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:324112 Barreira da Silva R, et al., Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. Nat Immunol. 2022 Apr;23(4):568-580
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory