Tln2 MGI Mouse Gene Detail - MGI:1917799

Symbol

Tln2
Name

talin 2
Synonyms

mKIAA0320

Feature Type

protein coding gene
IDs

MGI:1917799
NCBI Gene: 70549
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:67124369-67466985 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 36.39 cM
Mapping Data

2 experiments

SNPs within 2kb

10484 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917799	protein coding gene	Chr9:67124369-67541357 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034986	protein coding gene	Chr9:67098227-67450935 (-)
A/J	MGP_AJ_G0034966	protein coding gene	Chr9:64787580-65136073 (-)
AKR/J	MGP_AKRJ_G0034896	protein coding gene	Chr9:66324637-66681895 (-)
BALB/cJ	MGP_BALBcJ_G0034959	protein coding gene	Chr9:64516912-64873641 (-)
C3H/HeJ	MGP_C3HHeJ_G0034668	protein coding gene	Chr9:66866185-67225657 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035478	protein coding gene	Chr9:68945338-69308700 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032389	protein coding gene	Chr9:64421659-64610631 (-)
CAST/EiJ	MGP_CASTEiJ_G0033990	protein coding gene	Chr9:67094689-67455408 (-)
CBA/J	MGP_CBAJ_G0034640	protein coding gene	Chr9:71320446-71690197 (-)
DBA/2J	MGP_DBA2J_G0034799	protein coding gene	Chr9:64550708-64892309 (-)
FVB/NJ	MGP_FVBNJ_G0034741	protein coding gene	Chr9:63890147-64237053 (-)
LP/J	MGP_LPJ_G0034881	protein coding gene	Chr9:67378491-67732521 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034783	protein coding gene	Chr9:72511502-72866205 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035500	protein coding gene	Chr9:66450408-66803034 (-)
PWK/PhJ	MGP_PWKPhJ_G0033694	protein coding gene	Chr9:64781115-65109150 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033527	protein coding gene	Chr9:66760224-67108518 (-)
WSB/EiJ	MGP_WSBEiJ_G0034102	protein coding gene	Chr9:66345271-66694107 (-)

Human Ortholog

TLN2, talin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLN2, talin 2
Synonyms

ILWEQ
Links

HGNC:15447

NCBI Gene ID: 83660

neXtProt AC: NX_Q9Y4G6

UniProt: Q9Y4G6
Chr Location

15q22.2; chr15:62390526-62844631 (+) GRCh38

MGI Vertebrate Homology

Tln2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TLN2
Gene Tree

Tln2

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Phenotype Summary

7 phenotypes from 5 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

74
Targeted

3
Genomic Mutations

1 involving Tln2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

149 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal muscle morphology.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

23
cDNA Data

19
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tln2

ZFIN tln2a, tln2b

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All Sequences

104
RefSeq

30
UniProt

14
CCDS

CCDS52849.1

Ensembl

ENSMUSG00000052698 (Evidence)
NCBI Gene

70549

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052698	Ensembl Gene Model \| MGI Sequence Detail	342617	C57BL/6J	± kb
transcript	ENSMUST00000215784	Ensembl \| MGI Sequence Detail	8330	Not Applicable
polypeptide	ENSMUSP00000148901	Ensembl \| MGI Sequence Detail	2544	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000016382 talin-2

(term hierarchy)
PDB

3G9W
InterPro Domains

IPR036723 Alpha-catenin/vinculin-like superfamily

IPR019749 Band 4.1 domain

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR002558 I/LWEQ domain

IPR035964 I/LWEQ domain superfamily

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily

IPR037438 Talin-1/2, rod-segment

IPR015224 Talin, central

IPR036476 Talin, central domain superfamily

IPR032425 Talin, N-terminal F0 domain

IPR049108 Talin, R4 domain

IPR029071 Ubiquitin-like domain superfamily

IPR015009 Vinculin-binding site-containing domain
GlyGen

Q71LX4 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 20

Microarray probesets 7

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MGI:2143087, MGI:2143119, MGI:3034966

Summaries

All 68

Developmental Gene Expression 14

Gene Ontology 8

Phenotypes 20
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:322932 Noll NA, et al., Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload. Am J Physiol Heart Circ Physiol. 2022 Mar 25;

TSS for Tln2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90342	Chr9:67392468-67392482 (-)	74,510 bp
Tssr90341	Chr9:67336100-67336149 (-)	130,860 bp
Tssr90340	Chr9:67234949-67234970 (-)	232,025 bp
Tssr90339	Chr9:67234929-67234948 (-)	232,046 bp
Tssr90338	Chr9:67229244-67229255 (-)	237,735 bp
Tssr90337	Chr9:67225861-67225873 (-)	241,118 bp
Tssr90336	Chr9:67206579-67206590 (-)	260,400 bp
Tssr90335	Chr9:67206518-67206563 (-)	260,444 bp
Tssr90334	Chr9:67197570-67197574 (-)	269,413 bp
Tssr90333	Chr9:67174201-67174212 (-)	292,778 bp
Tssr90332	Chr9:67174182-67174192 (-)	292,798 bp
Tssr90331	Chr9:67169422-67169429 (-)	297,559 bp
Tssr90330	Chr9:67169369-67169388 (-)	297,606 bp
Tssr90329	Chr9:67158174-67158181 (-)	308,807 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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