Prxl2a MGI Mouse Gene Detail - MGI:1917814

Symbol

Prxl2a
Name

peroxiredoxin like 2A
Synonyms

5730469M10Rik, Adiporedoxin, Adrx, Fam213a

Feature Type

protein coding gene
IDs

MGI:1917814
NCBI Gene: 70564
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr14:40715697-40735745 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 22.36 cM
Mapping Data

2 experiments

SNPs within 2kb

678 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917814	protein coding gene	Chr14:40715692-40735790 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021193	protein coding gene	Chr14:34627347-34647421 (-)
A/J	MGP_AJ_G0021141	protein coding gene	Chr14:33278785-33298829 (-)
AKR/J	MGP_AKRJ_G0021118	protein coding gene	Chr14:34645300-34665341 (-)
BALB/cJ	MGP_BALBcJ_G0021145	protein coding gene	Chr14:33496372-33516800 (-)
C3H/HeJ	MGP_C3HHeJ_G0020928	protein coding gene	Chr14:34598854-34619118 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021577	protein coding gene	Chr14:36018698-36038858 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019139	protein coding gene	Chr14:32911365-32931751 (-)
CAST/EiJ	MGP_CASTEiJ_G0020453	protein coding gene	Chr14:34373495-34393528 (-)
CBA/J	MGP_CBAJ_G0020894	protein coding gene	Chr14:37236366-37259680 (-)
DBA/2J	MGP_DBA2J_G0021017	protein coding gene	Chr14:33237898-33258850 (-)
FVB/NJ	MGP_FVBNJ_G0021001	protein coding gene	Chr14:33174578-33194676 (-)
LP/J	MGP_LPJ_G0021086	protein coding gene	Chr14:34863981-34883989 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021027	protein coding gene	Chr14:36874278-36894379 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021610	protein coding gene	Chr14:34427374-34447449 (-)
PWK/PhJ	MGP_PWKPhJ_G0020201	protein coding gene	Chr14:32714144-32734483 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020025	protein coding gene	Chr14:34056531-34076898 (-)
WSB/EiJ	MGP_WSBEiJ_G0020508	protein coding gene	Chr14:34535903-34556063 (-)

Human Ortholog

PRXL2A, peroxiredoxin like 2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRXL2A, peroxiredoxin like 2A
Synonyms

Adrx, C10orf58, FAM213A, PAMM
Links

HGNC:28651

NCBI Gene ID: 84293

neXtProt AC: NX_Q9BRX8

UniProt: Q9BRX8
Chr Location

10q23.1; chr10:80407829-80437115 (+) GRCh38

MGI Vertebrate Homology

Prxl2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRXL2A
Gene Tree

Prxl2a

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
82 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Prxl2a
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced circulating adipokine levels and decreased collagen deposition in adipose tissue along with mild adipocyte ER stress and hyperinsulinemia.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

978
Tissues

41
cDNA Data

79
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prxl2a

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All Sequences

91
RefSeq

24
UniProt

8
CCDS

CCDS26957.1, CCDS84116.1

Ensembl

ENSMUSG00000021792 (Evidence)
NCBI Gene

70564

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021792	Ensembl Gene Model \| MGI Sequence Detail	20049	C57BL/6J	± kb
transcript	ENSMUST00000118466	Ensembl \| MGI Sequence Detail	1567	Not Applicable
polypeptide	ENSMUSP00000112377	Ensembl \| MGI Sequence Detail	229	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000031575 peroxiredoxin-like 2A

(term hierarchy)
InterPro Domains

IPR032801 Peroxiredoxin-like 2A/B/C

IPR036249 Thioredoxin-like superfamily

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All nucleic 79

cDNA 79

Microarray probesets 5

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MGI:2145754, MGI:6276237

Summaries

All 109

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 82
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:359170 Vadisiute A, et al., Glial cells undergo rapid changes following acute chemogenetic manipulation of cortical layer 5 projection neurons. Commun Biol. 2024 Oct 9;7(1):1286

TSS for Prxl2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128205	Chr14:40735710-40735774 (-)	3 bp
Tssr128204	Chr14:40730320-40730321 (-)	5,424 bp
Tssr128203	Chr14:40730244-40730255 (-)	5,495 bp
Tssr128202	Chr14:40730236-40730243 (-)	5,505 bp
Tssr128201	Chr14:40730213-40730232 (-)	5,522 bp
Tssr128200	Chr14:40730180-40730209 (-)	5,550 bp
Tssr128199	Chr14:40728839-40728869 (-)	6,891 bp
Tssr128198	Chr14:40726474-40726485 (-)	9,265 bp
Tssr128197	Chr14:40726412-40726424 (-)	9,327 bp
Tssr128196	Chr14:40726351-40726369 (-)	9,385 bp
Tssr128195	Chr14:40726330-40726341 (-)	9,409 bp
Tssr128194	Chr14:40726224-40726240 (-)	9,513 bp
Tssr128193	Chr14:40726183-40726217 (-)	9,545 bp
Tssr128192	Chr14:40716378-40716407 (-)	19,352 bp
Tssr128191	Chr14:40716274-40716297 (-)	19,459 bp
Tssr128190	Chr14:40716170-40716182 (-)	19,569 bp
Tssr128189	Chr14:40716022-40716038 (-)	19,715 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24