Abhd17b MGI Mouse Gene Detail - MGI:1917816 - abhydrolase domain containing 17B

Symbol

Abhd17b
Name

abhydrolase domain containing 17B
Synonyms

5730446C15Rik, Fam108b, MGC:40949

Feature Type

protein coding gene
IDs

MGI:1917816
NCBI Gene: 226016
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:21630549-21663001 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 15.54 cM
Mapping Data

1 experiment

SNPs within 2kb

927 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917816	protein coding gene	Chr19:21630483-21663002 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024980	protein coding gene	Chr19:19704048-19736579 (+)
A/J	MGP_AJ_G0024957	protein coding gene	Chr19:18636762-18668198 (+)
AKR/J	MGP_AKRJ_G0024927	protein coding gene	Chr19:19338581-19371578 (+)
BALB/cJ	MGP_BALBcJ_G0024956	protein coding gene	Chr19:18636533-18668258 (+)
C3H/HeJ	MGP_C3HHeJ_G0024714	protein coding gene	Chr19:19289541-19323052 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025398	protein coding gene	Chr19:20372253-20403933 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022817	protein coding gene	Chr19:18858710-18889362 (+)
CAST/EiJ	MGP_CASTEiJ_G0024182	protein coding gene	Chr19:18985776-19021697 (+)
CBA/J	MGP_CBAJ_G0024692	protein coding gene	Chr19:21200797-21242126 (+)
DBA/2J	MGP_DBA2J_G0024824	protein coding gene	Chr19:18644749-18676390 (+)
FVB/NJ	MGP_FVBNJ_G0024785	protein coding gene	Chr19:18499521-18531153 (+)
LP/J	MGP_LPJ_G0024908	protein coding gene	Chr19:19661774-19694040 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024812	protein coding gene	Chr19:21330122-21362662 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025453	protein coding gene	Chr19:19283832-19317404 (+)
PWK/PhJ	MGP_PWKPhJ_G0023931	protein coding gene	Chr19:18192676-18224930 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023736	protein coding gene	Chr19:18577386-18615825 (+)
WSB/EiJ	MGP_WSBEiJ_G0024250	protein coding gene	Chr19:19370846-19403837 (+)

Human Ortholog

ABHD17B, abhydrolase domain containing 17B, depalmitoylase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABHD17B, abhydrolase domain containing 17B, depalmitoylase
Synonyms

C9orf77, CGI-67, FAM108B1
Links

HGNC:24278

NCBI Gene ID: 51104

neXtProt AC: NX_Q5VST6

UniProt: Q5VST6
Chr Location

9q21.13; chr9:71862452-71911193 (-) GRCh38

MGI Vertebrate Homology

Abhd17b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABHD17B
Gene Tree

Abhd17b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Endonuclease-mediated

3
Gene trapped

74
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

41
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abhd17b

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS29700.1

Ensembl

ENSMUSG00000047368 (Evidence)
NCBI Gene

226016

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047368	Ensembl Gene Model \| MGI Sequence Detail	32453	C57BL/6J	± kb
transcript	ENSMUST00000052556	Ensembl \| MGI Sequence Detail	2259	Not Applicable
polypeptide	ENSMUSP00000056099	Ensembl \| MGI Sequence Detail	288	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032514 alpha/beta hydrolase domain-containing protein 17B

(term hierarchy)
EC

3.1.2.22
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR022742 Serine aminopeptidase, S33
GlyGen

Q7M759 1 site, 1 N-linked glycan (1 site)

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All nucleic 42

cDNA 42

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abhd17b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155500	Chr19:21630214-21630266 (+)	-309 bp
Tssr155501	Chr19:21630468-21630473 (+)	-78 bp
Tssr155502	Chr19:21630477-21630488 (+)	-66 bp
Tssr155503	Chr19:21630540-21630556 (+)	-1 bp
Tssr155504	Chr19:21630561-21630577 (+)	20 bp
Tssr155505	Chr19:21630640-21630665 (+)	104 bp
Tssr155506	Chr19:21630666-21630684 (+)	126 bp
Tssr155507	Chr19:21630687-21630709 (+)	149 bp
Tssr155508	Chr19:21630792-21630809 (+)	252 bp
Tssr155509	Chr19:21630846-21630871 (+)	310 bp
Tssr155510	Chr19:21630886-21630900 (+)	344 bp
Tssr155511	Chr19:21630919-21630930 (+)	376 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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