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Wdr36 Gene Detail
Summary
  • Symbol
    Wdr36
  • Name
    WD repeat domain 36
  • Synonyms
    5730444A13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917819
    NCBI Gene: 225348
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32970241-33000008 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    817 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917819
 protein coding gene Chr18:32970241-33000647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024230
 protein coding gene Chr18:31003483-31034760 (+)
A/J MGP_AJ_G0024196
 protein coding gene Chr18:29966529-29995745 (+)
AKR/J MGP_AKRJ_G0024165
 protein coding gene Chr18:30794962-30824203 (+)
BALB/cJ MGP_BALBcJ_G0024196
 protein coding gene Chr18:30040625-30069860 (+)
C3H/HeJ MGP_C3HHeJ_G0023964
 protein coding gene Chr18:30846534-30875747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024638
 protein coding gene Chr18:32110894-32141718 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022079
 protein coding gene Chr18:30173608-30203425 (+)
CAST/EiJ MGP_CASTEiJ_G0023439
 protein coding gene Chr18:30725883-30756982 (+)
CBA/J MGP_CBAJ_G0023932
 protein coding gene Chr18:33085703-33114916 (+)
DBA/2J MGP_DBA2J_G0024064
 protein coding gene Chr18:29645272-29674780 (+)
FVB/NJ MGP_FVBNJ_G0024030
 protein coding gene Chr18:29346693-29375949 (+)
LP/J MGP_LPJ_G0024145
 protein coding gene Chr18:31074003-31103198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024058
 protein coding gene Chr18:34406365-34439864 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024686
 protein coding gene Chr18:30641435-30670652 (+)
PWK/PhJ MGP_PWKPhJ_G0023182
 protein coding gene Chr18:29795791-29825619 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022991
 protein coding gene Chr18:30908451-30939556 (+)
WSB/EiJ MGP_WSBEiJ_G0023502
 protein coding gene Chr18:30561335-30592236 (+)



Homology
more
  • Human Ortholog
    WDR36, WD repeat domain 36
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR36, WD repeat domain 36
  • Synonyms
    GLC1G, TA-WDRP, TAWDRP, UTP21
  • Links
    NCBI Gene ID: 134430
    neXtProt AC: NX_Q8NI36
    UniProt: Q8NI36

  • Chr Location
    5q22.1; chr5:111092321-111130502 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human WDR36 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete embryonic lethality before implantation. In culture, homozygous mutant embryos fail to reach the blastocyst stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    16
  • cDNA Data
    124
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225348 NCBI Gene Model | MGI Sequence Detail 29768 C57BL/6J ±  kb
    transcript NM_001110015 RefSeq | MGI Sequence Detail 3226 C57BL/6  
    polypeptide NP_001103485 RefSeq | MGI Sequence Detail 899 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR007319 Small-subunit processome, Utp21
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 124

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory