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Cpm Gene Detail
Summary
  • Symbol
    Cpm
  • Name
    carboxypeptidase M
  • Synonyms
    1110060I01Rik, 5730456K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917824
    NCBI Gene: 70574
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117465405-117523257 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 66.19 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1651 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917824
 protein coding gene Chr10:117465405-117523257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017760
 protein coding gene Chr10:120576112-120635381 (+)
A/J MGP_AJ_G0017736
 protein coding gene Chr10:115850641-115907469 (+)
AKR/J MGP_AKRJ_G0017698
 protein coding gene Chr10:119253020-119312912 (+)
BALB/cJ MGP_BALBcJ_G0017699
 protein coding gene Chr10:116248546-116305354 (+)
C3H/HeJ MGP_C3HHeJ_G0017524
 protein coding gene Chr10:119475745-119533662 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018154
 protein coding gene Chr10:124723382-124785356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015835
 protein coding gene Chr10:110426482-110480187 (+)
CAST/EiJ MGP_CASTEiJ_G0017084
 protein coding gene Chr10:119770580-119839779 (+)
CBA/J MGP_CBAJ_G0017493
 protein coding gene Chr10:129661073-129721712 (+)
DBA/2J MGP_DBA2J_G0017598
 protein coding gene Chr10:114999989-115056101 (+)
FVB/NJ MGP_FVBNJ_G0017593
 protein coding gene Chr10:113963070-114020973 (+)
LP/J MGP_LPJ_G0017671
 protein coding gene Chr10:121120274-121180354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017622
 protein coding gene Chr10:132467100-132532712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018194
 protein coding gene Chr10:119321321-119380722 (+)
PWK/PhJ MGP_PWKPhJ_G0016868
 protein coding gene Chr10:115093712-115152918 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016658
 protein coding gene Chr10:118095374-118161398 (+)
WSB/EiJ MGP_WSBEiJ_G0017146
 protein coding gene Chr10:119508834-119568446 (+)



Homology
more
  • Human Ortholog
    CPM, carboxypeptidase M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPM, carboxypeptidase M
  • Links
    NCBI Gene ID: 1368
    neXtProt AC: NX_P14384
    UniProt: P14384

  • Chr Location
    12q15; chr12:68842197-68971570 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    74
  • cDNA Data
    17
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70574 NCBI Gene Model | MGI Sequence Detail 57853 C57BL/6J ±  kb
    transcript NM_027468 RefSeq | MGI Sequence Detail 5195 Not Specified  
    polypeptide Q80V42 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005813 carboxypeptidase M
      (term hierarchy)
    • EC
      3.4.17.12
    • InterPro Domains
      IPR008969 Carboxypeptidase-like, regulatory domain superfamily
      IPR033842 Carboxypeptidase M, N-terminal domain
      IPR000834 Peptidase M14, carboxypeptidase A
      IPR050753 Peptidase M14 domain-containing protein
    • GlyGen
      Q80V42 5 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1913457
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 11
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory