Itprid2 MGI Mouse Gene Detail - MGI:1917849 - ITPR interacting domain containing 2

Symbol

Itprid2
Name

ITPR interacting domain containing 2
Synonyms

CS-1, CS1, KRAP, mKIAA1927, SPAG13, Ssfa2

Feature Type

protein coding gene
IDs

MGI:1917849
NCBI Gene: 70599
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:79465696-79503310 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 47.58 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

940 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917849	protein coding gene	Chr2:79419207-79503310 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025879	protein coding gene	Chr2:80191667-80230530 (+)
A/J	MGP_AJ_G0025856	protein coding gene	Chr2:77091355-77128919 (+)
AKR/J	MGP_AKRJ_G0025825	protein coding gene	Chr2:79100597-79138117 (+)
BALB/cJ	MGP_BALBcJ_G0025852	protein coding gene	Chr2:77215838-77253591 (+)
C3H/HeJ	MGP_C3HHeJ_G0025611	protein coding gene	Chr2:79333154-79371554 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026298	protein coding gene	Chr2:82557776-82596487 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023701	protein coding gene	Chr2:74340629-74378582 (+)
CAST/EiJ	MGP_CASTEiJ_G0025073	protein coding gene	Chr2:79756150-79796322 (+)
CBA/J	MGP_CBAJ_G0025592	protein coding gene	Chr2:85519913-85562591 (+)
DBA/2J	MGP_DBA2J_G0025723	protein coding gene	Chr2:76640199-76677304 (+)
FVB/NJ	MGP_FVBNJ_G0025685	protein coding gene	Chr2:76007193-76044604 (+)
LP/J	MGP_LPJ_G0025811	protein coding gene	Chr2:80031417-80068873 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025716	protein coding gene	Chr2:87380168-87424892 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026354	protein coding gene	Chr2:79276752-79319032 (+)
PWK/PhJ	MGP_PWKPhJ_G0024816	protein coding gene	Chr2:76585934-76627833 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024622	protein coding gene	Chr2:79548063-79585550 (+)
WSB/EiJ	MGP_WSBEiJ_G0025142	protein coding gene	Chr2:79902643-79940561 (+)

Human Ortholog

ITPRID2, ITPR interacting domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITPRID2, ITPR interacting domain containing 2
Synonyms

CS-1, CS1, KRAP, SPAG13, SSFA2
Links

HGNC:11319

NCBI Gene ID: 6744

neXtProt AC: NX_P28290

UniProt: P28290
Chr Location

2q31.3; chr2:181891730-181930738 (+) GRCh38

MGI Vertebrate Homology

Itprid2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITPRID2
Gene Tree

Itprid2

less

Phenotype Summary

27 phenotypes from 1 allele in 2 genetic backgrounds
2 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

4
Genomic Mutations

3 involving Itprid2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display decreased body weight, resistance to diet induced obesity, increased food intake, decreased adipose tissue mass, elevated metabolic rate, abnormal glucose homeostasis, and abnormal hormone levels.

less

All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

100

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itprid2

less

All Sequences

56
RefSeq

9
UniProt

4
CCDS

CCDS16170.1

Ensembl

ENSMUSG00000027007 (Evidence)
NCBI Gene

70599

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027007	Ensembl Gene Model \| MGI Sequence Detail	37615	C57BL/6J	± kb
transcript	ENSMUST00000111785	Ensembl \| MGI Sequence Detail	5168	Not Applicable
polypeptide	ENSMUSP00000107415	Ensembl \| MGI Sequence Detail	1252	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015652 protein ITPRID2

(term hierarchy)
InterPro Domains

IPR029325 ITPR-interacting domain

IPR043444 Protein TESPA1-like

IPR029326 Sperm-specific antigen 2, C-terminal

less

All nucleic 100

cDNA 100

Microarray probesets 3

less

MGI:6192113

Summaries

All 37

Gene Ontology 3

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Itprid2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18584	Chr2:79465614-79465634 (+)	-72 bp
Tssr18585	Chr2:79465644-79465664 (+)	-42 bp
Tssr18586	Chr2:79465714-79465754 (+)	38 bp
Tssr18587	Chr2:79465760-79465785 (+)	77 bp
Tssr18588	Chr2:79465788-79465807 (+)	102 bp
Tssr18589	Chr2:79465943-79465994 (+)	273 bp
Tssr18590	Chr2:79465998-79466015 (+)	311 bp
Tssr18591	Chr2:79469538-79469551 (+)	3,849 bp
Tssr18592	Chr2:79474870-79474895 (+)	9,187 bp
Tssr18593	Chr2:79482345-79482368 (+)	16,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24