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Mutyh Gene Detail
Summary
  • Symbol
    Mutyh
  • Name
    mutY DNA glycosylase
  • Synonyms
    5730495A01Rik, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, Myh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917853
    NCBI Gene: 70603
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116664920-116676637 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.34 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917853
 protein coding gene Chr4:116664846-116676641 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028636
 protein coding gene Chr4:117740694-117753393 (+)
A/J MGP_AJ_G0028597
 protein coding gene Chr4:113208218-113220232 (+)
AKR/J MGP_AKRJ_G0028547
 protein coding gene Chr4:115669838-115683413 (+)
BALB/cJ MGP_BALBcJ_G0028618
 protein coding gene Chr4:113841796-113853288 (+)
C3H/HeJ MGP_C3HHeJ_G0028332
 protein coding gene Chr4:117233432-117250348 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029059
 protein coding gene Chr4:122280412-122293153 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026343
 protein coding gene Chr4:107255346-107266912 (+)
CAST/EiJ MGP_CASTEiJ_G0027766
 protein coding gene Chr4:114464401-114478375 (+)
CBA/J MGP_CBAJ_G0028299
 protein coding gene Chr4:125614977-125626407 (+)
DBA/2J MGP_DBA2J_G0028447
 protein coding gene Chr4:113845040-113860539 (+)
FVB/NJ MGP_FVBNJ_G0028415
 protein coding gene Chr4:112343729-112355529 (+)
LP/J MGP_LPJ_G0028549
 protein coding gene Chr4:117928809-117940356 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028442
 protein coding gene Chr4:130590859-130602329 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029096
 protein coding gene Chr4:116816333-116829143 (+)
PWK/PhJ MGP_PWKPhJ_G0027492
 protein coding gene Chr4:110625748-110637697 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027315
 protein coding gene Chr4:113094025-113105520 (+)
WSB/EiJ MGP_WSBEiJ_G0027845
 protein coding gene Chr4:116691204-116703178 (+)



Homology
more
  • Human Ortholog
    MUTYH, mutY DNA glycosylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUTYH, mutY DNA glycosylase
  • Synonyms
    MYH
  • Links
    NCBI Gene ID: 4595
    neXtProt AC: NX_Q9UIF7
    UniProt: Q9UIF7

  • Chr Location
    1p34.1; chr1:45329163-45340893 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human MUTYH associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Mutyh
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    36 strains or lines available
Homozygous mutant mice are viable and show no increase in tumor incidence relative to wild-type through 17 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    22
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028687 Ensembl Gene Model | MGI Sequence Detail 11718 C57BL/6J ±  kb
transcript ENSMUST00000102699 Ensembl | MGI Sequence Detail 1654 Not Applicable  
polypeptide ENSMUSP00000099760 Ensembl | MGI Sequence Detail 515 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 3
References
more
  • Summaries
    All 87
    Gene Ontology 10
    Phenotypes 44
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:324402 Mizuno Y, et al., MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease. Oxid Med Cell Longev. 2021;2021:8635088
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory