Dnajb14 MGI Mouse Gene Detail - MGI:1917854 - DnaJ heat shock protein family (Hsp40) member B14

Symbol

Dnajb14
Name

DnaJ heat shock protein family (Hsp40) member B14
Synonyms

5730496F10Rik

Feature Type

protein coding gene
IDs

MGI:1917854
NCBI Gene: 70604
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr3:137572801-137619350 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 63.94 cM
Mapping Data

1 experiment

SNPs within 2kb

1529 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917854	protein coding gene	Chr3:137572801-137622318 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027918	protein coding gene	Chr3:140888898-140946709 (+)
A/J	MGP_AJ_G0027875	protein coding gene	Chr3:135915359-135963648 (+)
AKR/J	MGP_AKRJ_G0027841	protein coding gene	Chr3:139526781-139577153 (+)
BALB/cJ	MGP_BALBcJ_G0027888	protein coding gene	Chr3:135719558-135771773 (+)
C3H/HeJ	MGP_C3HHeJ_G0027617	protein coding gene	Chr3:139859055-139909319 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028331	protein coding gene	Chr3:145758613-145808899 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025669	protein coding gene	Chr3:131019069-131066440 (+)
CAST/EiJ	MGP_CASTEiJ_G0027073	protein coding gene	Chr3:139619270-139668685 (+)
CBA/J	MGP_CBAJ_G0027594	protein coding gene	Chr3:150716597-150767344 (+)
DBA/2J	MGP_DBA2J_G0027733	protein coding gene	Chr3:135038349-135086513 (+)
FVB/NJ	MGP_FVBNJ_G0027700	protein coding gene	Chr3:132500234-132546184 (+)
LP/J	MGP_LPJ_G0027843	protein coding gene	Chr3:142295960-142350232 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027732	protein coding gene	Chr3:158825352-158874214 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028389	protein coding gene	Chr3:139070136-139121209 (+)
PWK/PhJ	MGP_PWKPhJ_G0026797	protein coding gene	Chr3:134784166-134837388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026624	protein coding gene	Chr3:137159362-137209155 (+)
WSB/EiJ	MGP_WSBEiJ_G0027153	protein coding gene	Chr3:139888621-139938625 (+)

Human Ortholog

DNAJB14, DnaJ heat shock protein family (Hsp40) member B14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB14, DnaJ heat shock protein family (Hsp40) member B14
Synonyms

EGNR9427, PRO34683
Links

HGNC:25881

NCBI Gene ID: 79982

neXtProt AC: NX_Q8TBM8

UniProt: Q8TBM8
Chr Location

4q23; chr4:99896248-99946618 (-) GRCh38

MGI Vertebrate Homology

Dnajb14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJB14
Gene Tree

Dnajb14

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Dnajb14
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb14

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All Sequences

47
RefSeq

9
UniProt

2
CCDS

CCDS51077.1

Ensembl

ENSMUSG00000074212 (Evidence)
NCBI Gene

70604

			Length	Strain/Species	Flank
genomic	70604	NCBI Gene Model \| MGI Sequence Detail	46550	C57BL/6J	± kb
transcript	NM_001033155	RefSeq \| MGI Sequence Detail	1851	C57BL/6
polypeptide	Q149L6	UniProt \| EBI \| MGI Sequence Detail	379	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006575 DnaJ homolog subfamily B member 14

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR051100 DnaJ subfamily B/C chaperone co-factors

IPR015399 Domain of unknown function DUF1977, DnaJ-like

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 35

Diseases 1

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajb14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31916	Chr3:137571629-137571632 (+)	-1,170 bp
Tssr31917	Chr3:137571661-137571699 (+)	-1,121 bp
Tssr31918	Chr3:137573519-137573558 (+)	738 bp
Tssr31919	Chr3:137573568-137573595 (+)	781 bp
Tssr31920	Chr3:137573620-137573637 (+)	828 bp
Tssr31921	Chr3:137573639-137573674 (+)	856 bp
Tssr31922	Chr3:137573719-137573725 (+)	921 bp
Tssr31923	Chr3:137573823-137573830 (+)	1,026 bp
Tssr31924	Chr3:137573838-137573878 (+)	1,057 bp
Tssr31925	Chr3:137573882-137573890 (+)	1,085 bp
Tssr31926	Chr3:137588423-137588426 (+)	15,624 bp
Tssr31927	Chr3:137588574-137588581 (+)	15,777 bp
Tssr31928	Chr3:137614224-137614240 (+)	41,431 bp
Tssr31929	Chr3:137616431-137616444 (+)	43,637 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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