Btbd7 MGI Mouse Gene Detail - MGI:1917858

Symbol

Btbd7
Name

BTB domain containing 7
Synonyms

5730507E09Rik, E130118E17Rik, FUP1, mKIAA1525

Feature Type

protein coding gene
IDs

MGI:1917858
NCBI Gene: 238386
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:102747056-102844730 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.25 cM
Mapping Data

2 experiments

SNPs within 2kb

1706 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917858	protein coding gene	Chr12:102747056-102844733 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020041	protein coding gene	Chr12:104443208-104531397 (-)
A/J	MGP_AJ_G0019997	protein coding gene	Chr12:100424037-100515627 (-)
AKR/J	MGP_AKRJ_G0019973	protein coding gene	Chr12:103266725-103351274 (-)
BALB/cJ	MGP_BALBcJ_G0019983	protein coding gene	Chr12:100777162-100869114 (-)
C3H/HeJ	MGP_C3HHeJ_G0019785	protein coding gene	Chr12:103740140-103832659 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020432	protein coding gene	Chr12:107683385-107784938 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018045	protein coding gene	Chr12:97475830-97556554 (-)
CAST/EiJ	MGP_CASTEiJ_G0019331	protein coding gene	Chr12:98586689-98678140 (-)
CBA/J	MGP_CBAJ_G0019757	protein coding gene	Chr12:111685698-111786109 (-)
DBA/2J	MGP_DBA2J_G0019868	protein coding gene	Chr12:99944092-100032862 (-)
FVB/NJ	MGP_FVBNJ_G0019857	protein coding gene	Chr12:98674051-98769460 (-)
LP/J	MGP_LPJ_G0019944	protein coding gene	Chr12:104283718-104377266 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019897	protein coding gene	Chr12:115145923-115250460 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020461	protein coding gene	Chr12:102791461-102883715 (-)
PWK/PhJ	MGP_PWKPhJ_G0019094	protein coding gene	Chr12:94501062-94591529 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018890	protein coding gene	Chr12:96979404-97068502 (-)
WSB/EiJ	MGP_WSBEiJ_G0019385	protein coding gene	Chr12:103675145-103770689 (-)

Human Ortholog

BTBD7, BTB domain containing 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BTBD7, BTB domain containing 7
Synonyms

FUP1
Links

HGNC:18269

NCBI Gene ID: 55727

neXtProt AC: NX_Q9P203

UniProt: Q9P203
Chr Location

14q32.12; chr14:93237550-93333092 (-) GRCh38

MGI Vertebrate Homology

Btbd7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BTBD7
Gene Tree

Btbd7

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

5
Genomic Mutations

1 involving Btbd7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display fetal and postnatal lethality, impaired branching morphogenesis in the submandibular salivary gland, lung and kidney, and impaired migration of submandibular gland outer bud cells.

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All GO Annotations

4
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

44
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase btbd7

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All Sequences

53
RefSeq

10
UniProt

1
CCDS

CCDS26125.1

Ensembl

ENSMUSG00000041702 (Evidence)
NCBI Gene

238386

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041702	Ensembl Gene Model \| MGI Sequence Detail	97675	C57BL/6J	± kb
transcript	ENSMUST00000045652	Ensembl \| MGI Sequence Detail	4035	Not Applicable
polypeptide	ENSMUSP00000046951	Ensembl \| MGI Sequence Detail	1130	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031836 BTB/POZ domain-containing protein 7

(term hierarchy)
InterPro Domains

IPR047936 BTBD7, BACK domain

IPR047934 BTBD7, first BTB/POZ domain

IPR047935 BTBD7, second BTB/POZ domain

IPR011705 BTB/Kelch-associated

IPR000210 BTB/POZ domain

IPR042345 BTB/POZ domain-containing protein 7

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 7

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MGI:2443368

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Btbd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117451	Chr12:102844714-102844736 (-)	5 bp
Tssr117450	Chr12:102844667-102844708 (-)	42 bp
Tssr117448	Chr12:102822007-102822044 (-)	22,704 bp
Tssr117447	Chr12:102784604-102784607 (-)	60,124 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24