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Med26 Gene Detail
Summary
  • Symbol
    Med26
  • Name
    mediator complex subunit 26
  • Synonyms
    5730493L18Rik, Crsp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917875
    NCBI Gene: 70625
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73248405-73302114 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917875
 protein coding gene Chr8:73248402-73302154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033785
 protein coding gene Chr8:72996707-73052729 (-)
A/J MGP_AJ_G0033767
 protein coding gene Chr8:70028539-70084414 (-)
AKR/J MGP_AKRJ_G0033694
 protein coding gene Chr8:72104180-72178308 (-)
BALB/cJ MGP_BALBcJ_G0033761
 protein coding gene Chr8:70174333-70227622 (-)
C3H/HeJ MGP_C3HHeJ_G0033470
 protein coding gene Chr8:72739468-72797438 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034281
 protein coding gene Chr8:75764413-75824175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031222
 protein coding gene Chr8:64551762-64606593 (-)
CAST/EiJ MGP_CASTEiJ_G0032799
 protein coding gene Chr8:72085760-72144211 (-)
CBA/J MGP_CBAJ_G0033449
 protein coding gene Chr8:78473915-78533264 (-)
DBA/2J MGP_DBA2J_G0033603
 protein coding gene Chr8:69779662-69834373 (-)
FVB/NJ MGP_FVBNJ_G0033548
 protein coding gene Chr8:68858963-68912757 (-)
LP/J MGP_LPJ_G0033692
 protein coding gene Chr8:73079291-73134112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033592
 protein coding gene Chr8:80955947-81011206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034298
 protein coding gene Chr8:72187268-72251631 (-)
PWK/PhJ MGP_PWKPhJ_G0032505
 protein coding gene Chr8:69041617-69099044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032343
 protein coding gene Chr8:71112798-71168762 (-)
WSB/EiJ MGP_WSBEiJ_G0032914
 protein coding gene Chr8:72484391-72541027 (-)



Homology
more
  • Human Ortholog
    MED26, mediator complex subunit 26
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED26, mediator complex subunit 26
  • Synonyms
    CRSP7, CRSP70
  • Links
    NCBI Gene ID: 9441
    neXtProt AC: NX_O95402
    UniProt: O95402

  • Chr Location
    19p13.11; chr19:16574907-16629062 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    59
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    56
  • Genomic Mutations
    1 involving Med26
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    49 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    128
  • cDNA Data
    10
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045248 Ensembl Gene Model | MGI Sequence Detail 53710 C57BL/6J ±  kb
transcript ENSMUST00000058534 Ensembl | MGI Sequence Detail 2997 Not Applicable  
polypeptide ENSMUSP00000058697 Ensembl | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010298 mediator of RNA polymerase II transcription subunit 26
    (term hierarchy)
  • PDB
    8T1I
  • InterPro Domains
    IPR031416 Mediator complex subunit 26, C-terminal domain
    IPR031417 Mediator complex subunit 26, middle domain
    IPR042376 Mediator of RNA polymerase II transcription subunit 26
    IPR035441 TFIIS/LEDGF domain superfamily
    IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
    IPR017923 Transcription factor IIS, N-terminal
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142528, MGI:2142791
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory