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Adgra3 Gene Detail
Summary
  • Symbol
    Adgra3
  • Name
    adhesion G protein-coupled receptor A3
  • Synonyms
    3830613O22Rik, Gpr125, Tem5-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917943
    NCBI Gene: 70693
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:50117293-50216338 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 26.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2922 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917943
 protein coding gene Chr5:50117293-50216348 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029541
 protein coding gene Chr5:48834796-48937597 (-)
A/J MGP_AJ_G0029509
 protein coding gene Chr5:47120252-47217869 (-)
AKR/J MGP_AKRJ_G0029457
 protein coding gene Chr5:48724316-48825047 (-)
BALB/cJ MGP_BALBcJ_G0029518
 protein coding gene Chr5:47611184-47711830 (-)
C3H/HeJ MGP_C3HHeJ_G0029241
 protein coding gene Chr5:48888513-48989769 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029972
 protein coding gene Chr5:50948666-51051791 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027212
 protein coding gene Chr5:43993098-44090014 (-)
CAST/EiJ MGP_CASTEiJ_G0028649
 protein coding gene Chr5:47868300-47982077 (-)
CBA/J MGP_CBAJ_G0029210
 protein coding gene Chr5:52462126-52567491 (-)
DBA/2J MGP_DBA2J_G0029356
 protein coding gene Chr5:47189465-47287338 (-)
FVB/NJ MGP_FVBNJ_G0029316
 protein coding gene Chr5:46555150-46662383 (-)
LP/J MGP_LPJ_G0029441
 protein coding gene Chr5:49283111-49386638 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029344
 protein coding gene Chr5:53530468-53637051 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030005
 protein coding gene Chr5:48271907-48369649 (-)
PWK/PhJ MGP_PWKPhJ_G0028373
 protein coding gene Chr5:46270903-46368608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028207
 protein coding gene Chr5:47645675-47743703 (-)
WSB/EiJ MGP_WSBEiJ_G0028730
 protein coding gene Chr5:48304014-48405627 (-)



Homology
more
  • Human Ortholog
    ADGRA3, adhesion G protein-coupled receptor A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRA3, adhesion G protein-coupled receptor A3
  • Synonyms
    GPR125, PGR21, TEM5L
  • Links
    NCBI Gene ID: 166647
    neXtProt AC: NX_Q8IWK6
    UniProt: Q8IWK6

  • Chr Location
    4p15.2; chr4:22345071-22516066 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    26 phenotype references
Homozygous mutant mice are fertile and grossly normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1100
  • Tissues
    100
  • cDNA Data
    166
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70693 NCBI Gene Model | MGI Sequence Detail 99046 C57BL/6J ±  kb
transcript NM_133911 RefSeq | MGI Sequence Detail 4475 C57BL/6  
polypeptide Q7TT36 UniProt | EBI | MGI Sequence Detail 1310 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 169
    cDNA 166
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141092
References
more
  • Summaries
    All 59
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:338754 Nybo ML, et al., Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice. FASEB J. 2023 Feb;37(2):e22781
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory