Rasgef1a MGI Mouse Gene Detail - MGI:1917977 - RasGEF domain family, member 1A

Symbol

Rasgef1a
Name

RasGEF domain family, member 1A
Synonyms

6330404M18Rik

Feature Type

protein coding gene
IDs

MGI:1917977
NCBI Gene: 70727
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:117988466-118068507 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 55.85 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

2455 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917977	protein coding gene	Chr6:117988399-118068507 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031182	protein coding gene	Chr6:120742391-120830497 (+)
A/J	MGP_AJ_G0031151	protein coding gene	Chr6:116121567-116202203 (+)
AKR/J	MGP_AKRJ_G0031082	protein coding gene	Chr6:119243007-119331929 (+)
BALB/cJ	MGP_BALBcJ_G0031162	protein coding gene	Chr6:115898659-115981181 (+)
C3H/HeJ	MGP_C3HHeJ_G0030547	protein coding gene	Chr6:64963384-65047778 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031620	protein coding gene	Chr6:123920175-123945283 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028782	protein coding gene	Chr6:113049603-113131730 (+)
CAST/EiJ	MGP_CASTEiJ_G0030269	protein coding gene	Chr6:119616936-119710537 (+)
CBA/J	MGP_CBAJ_G0030845	protein coding gene	Chr6:128804476-128829561 (+)
DBA/2J	MGP_DBA2J_G0031001	protein coding gene	Chr6:115020785-115106288 (+)
FVB/NJ	MGP_FVBNJ_G0030953	protein coding gene	Chr6:114152787-114237835 (+)
LP/J	MGP_LPJ_G0031080	protein coding gene	Chr6:120770439-120859029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030987	protein coding gene	Chr6:132909389-132934347 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031649	protein coding gene	Chr6:119331689-119357889 (+)
PWK/PhJ	MGP_PWKPhJ_G0029984	protein coding gene	Chr6:114031005-114120834 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029813	protein coding gene	Chr6:117992978-118081229 (+)
WSB/EiJ	MGP_WSBEiJ_G0030352	protein coding gene	Chr6:119598578-119625477 (+)

Human Ortholog

RASGEF1A, RasGEF domain family member 1A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASGEF1A, RasGEF domain family member 1A
Synonyms

CG4853
Links

HGNC:24246

NCBI Gene ID: 221002

neXtProt AC: NX_Q8N9B8

UniProt: Q8N9B8
Chr Location

10q11.21; chr10:43194535-43267065 (-) GRCh38

MGI Vertebrate Homology

Rasgef1a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RASGEF1A
Gene Tree

Rasgef1a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Gene trapped

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

4
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasgef1a

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All Sequences

54
RefSeq

11
UniProt

5
CCDS

CCDS51883.1, CCDS85141.1, CCDS90110.1

Ensembl

ENSMUSG00000030134 (Evidence)
NCBI Gene

70727

			Length	Strain/Species	Flank
genomic	70727	NCBI Gene Model \| MGI Sequence Detail	80042	C57BL/6J	± kb
transcript	NM_001362105	RefSeq \| MGI Sequence Detail	3379	C57BL/6
polypeptide	NP_001349032	RefSeq \| MGI Sequence Detail	498	C57BL/6

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UniProt

5 Sequences
InterPro Domains

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR008937 Ras-like guanine nucleotide exchange factor

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:2141473

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rasgef1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58477	Chr6:117988274-117988356 (+)	-151 bp
Tssr58478	Chr6:117988409-117988457 (+)	-33 bp
Tssr1981	Chr6:117988458-117988472 (+)	-1 bp
Tssr58479	Chr6:118031792-118031800 (+)	43,330 bp
Tssr58480	Chr6:118035146-118035157 (+)	46,686 bp
Tssr58481	Chr6:118043317-118043371 (+)	54,878 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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