Tspan2 MGI Mouse Gene Detail - MGI:1917997

Symbol

Tspan2
Name

tetraspanin 2
Synonyms

6330415F13Rik, B230119D02Rik

Feature Type

protein coding gene
IDs

MGI:1917997
NCBI Gene: 70747
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:102642086-102679626 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.25 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

865 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917997	protein coding gene	Chr3:102641845-102708829 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027683	protein coding gene	Chr3:103968300-104043341 (+)
A/J	MGP_AJ_G0027642	protein coding gene	Chr3:100664110-100746541 (+)
AKR/J	MGP_AKRJ_G0027608	protein coding gene	Chr3:103158451-103225827 (+)
BALB/cJ	MGP_BALBcJ_G0027655	protein coding gene	Chr3:100428475-100494989 (+)
C3H/HeJ	MGP_C3HHeJ_G0027384	protein coding gene	Chr3:103457933-103527311 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028098	protein coding gene	Chr3:107810793-107889875 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025439	protein coding gene	Chr3:96832909-96900737 (+)
CAST/EiJ	MGP_CASTEiJ_G0026841	protein coding gene	Chr3:102576042-102655078 (+)
CBA/J	MGP_CBAJ_G0027359	protein coding gene	Chr3:111484339-111561359 (+)
DBA/2J	MGP_DBA2J_G0027502	protein coding gene	Chr3:99915839-99982546 (+)
FVB/NJ	MGP_FVBNJ_G0027470	protein coding gene	Chr3:97851688-97918628 (+)
LP/J	MGP_LPJ_G0027609	protein coding gene	Chr3:105310698-105381805 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027500	protein coding gene	Chr3:117629908-117712728 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028153	protein coding gene	Chr3:102664841-102731320 (+)
PWK/PhJ	MGP_PWKPhJ_G0026567	protein coding gene	Chr3:99673256-99741014 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026389	protein coding gene	Chr3:100753154-100819160 (+)
WSB/EiJ	MGP_WSBEiJ_G0026920	protein coding gene	Chr3:103215323-103287983 (+)

Human Ortholog

TSPAN2, tetraspanin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN2, tetraspanin 2
Synonyms

NET3, TSN2, TSPAN-2
Links

HGNC:20659

NCBI Gene ID: 10100

neXtProt AC: NX_O60636

UniProt: O60636
Chr Location

1p13.2; chr1:115048011-115089503 (-) GRCh38

MGI Vertebrate Homology

Tspan2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TSPAN2
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Tspan2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available

Mice are viable and fertile with mild astrogliosis and microgliosis in the absence of axonal pathology.

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All GO Annotations

13
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

57
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan2

ZFIN tspan2a

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All Sequences

50
RefSeq

4
UniProt

5
CCDS

CCDS17688.1, CCDS57249.1

Ensembl

ENSMUSG00000027858 (Evidence)
NCBI Gene

70747

			Length	Strain/Species	Flank
genomic	70747	NCBI Gene Model \| MGI Sequence Detail	37541	C57BL/6J	± kb
transcript	NM_027533	RefSeq \| MGI Sequence Detail	4261	C57BL/6
polypeptide	Q922J6	UniProt \| EBI \| MGI Sequence Detail	221	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016745 tetraspanin-2

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q922J6 2 sites, 14 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 57

cDNA 57

Microarray probesets 6

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MGI:1925095, MGI:2139954

Summaries

All 36

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:296151 Liu J, et al., Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940

TSS for Tspan2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30938	Chr3:102641812-102641846 (+)	-257 bp
Tssr30939	Chr3:102642219-102642268 (+)	158 bp
Tssr30940	Chr3:102642272-102642293 (+)	197 bp
Tssr30941	Chr3:102642518-102642552 (+)	449 bp
Tssr30942	Chr3:102655496-102655500 (+)	13,412 bp
Tssr30943	Chr3:102668211-102668222 (+)	26,131 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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