About   Help   FAQ
Tspan2 Gene Detail
Summary
  • Symbol
    Tspan2
  • Name
    tetraspanin 2
  • Synonyms
    6330415F13Rik, B230119D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917997
    NCBI Gene: 70747
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102642086-102679626 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    865 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917997
 protein coding gene Chr3:102641845-102708829 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027683
 protein coding gene Chr3:103968300-104043341 (+)
A/J MGP_AJ_G0027642
 protein coding gene Chr3:100664110-100746541 (+)
AKR/J MGP_AKRJ_G0027608
 protein coding gene Chr3:103158451-103225827 (+)
BALB/cJ MGP_BALBcJ_G0027655
 protein coding gene Chr3:100428475-100494989 (+)
C3H/HeJ MGP_C3HHeJ_G0027384
 protein coding gene Chr3:103457933-103527311 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028098
 protein coding gene Chr3:107810793-107889875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025439
 protein coding gene Chr3:96832909-96900737 (+)
CAST/EiJ MGP_CASTEiJ_G0026841
 protein coding gene Chr3:102576042-102655078 (+)
CBA/J MGP_CBAJ_G0027359
 protein coding gene Chr3:111484339-111561359 (+)
DBA/2J MGP_DBA2J_G0027502
 protein coding gene Chr3:99915839-99982546 (+)
FVB/NJ MGP_FVBNJ_G0027470
 protein coding gene Chr3:97851688-97918628 (+)
LP/J MGP_LPJ_G0027609
 protein coding gene Chr3:105310698-105381805 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027500
 protein coding gene Chr3:117629908-117712728 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028153
 protein coding gene Chr3:102664841-102731320 (+)
PWK/PhJ MGP_PWKPhJ_G0026567
 protein coding gene Chr3:99673256-99741014 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026389
 protein coding gene Chr3:100753154-100819160 (+)
WSB/EiJ MGP_WSBEiJ_G0026920
 protein coding gene Chr3:103215323-103287983 (+)



Homology
more
  • Human Ortholog
    TSPAN2, tetraspanin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN2, tetraspanin 2
  • Synonyms
    NET3, TSN2, TSPAN-2
  • Links
    NCBI Gene ID: 10100
    neXtProt AC: NX_O60636
    UniProt: O60636

  • Chr Location
    1p13.2; chr1:115048011-115089503 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice are viable and fertile with mild astrogliosis and microgliosis in the absence of axonal pathology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    57
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70747 NCBI Gene Model | MGI Sequence Detail 37541 C57BL/6J ±  kb
transcript NM_027533 RefSeq | MGI Sequence Detail 4261 C57BL/6  
polypeptide Q922J6 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 57
    cDNA 57

    Microarray probesets 6
Other
Accession IDs
less
MGI:1925095, MGI:2139954
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:296151 Liu J, et al., Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory