Nolc1 MGI Mouse Gene Detail - MGI:1918019 - nucleolar and coiled-body phosphoprotein 1

Symbol

Nolc1
Name

nucleolar and coiled-body phosphoprotein 1
Synonyms

3230402K17Rik, mKIAA0035, NOPP140, P130

Feature Type

protein coding gene
IDs

MGI:1918019
NCBI Gene: 70769
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:46064302-46073969 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.75 cM
Mapping Data

2 experiments

SNPs within 2kb

397 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918019	protein coding gene	Chr19:46064286-46073982 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025199	protein coding gene	Chr19:45738087-45751357 (+)
A/J	MGP_AJ_G0025175	protein coding gene	Chr19:43488696-43498463 (+)
AKR/J	MGP_AKRJ_G0025144	protein coding gene	Chr19:44897094-44906744 (+)
BALB/cJ	MGP_BALBcJ_G0025170	protein coding gene	Chr19:43544459-43554805 (+)
C3H/HeJ	MGP_C3HHeJ_G0024930	protein coding gene	Chr19:45067397-45078259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025613	protein coding gene	Chr19:46874073-46887100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023027	protein coding gene	Chr19:42728534-42737559 (+)
CAST/EiJ	MGP_CASTEiJ_G0024395	protein coding gene	Chr19:44843369-44854950 (+)
CBA/J	MGP_CBAJ_G0024910	protein coding gene	Chr19:49237360-49246952 (+)
DBA/2J	MGP_DBA2J_G0025042	protein coding gene	Chr19:43309413-43320577 (+)
FVB/NJ	MGP_FVBNJ_G0025003	protein coding gene	Chr19:43083681-43093863 (+)
LP/J	MGP_LPJ_G0025128	protein coding gene	Chr19:45648192-45659111 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025034	protein coding gene	Chr19:48593048-48604042 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025671	protein coding gene	Chr19:45004051-45013700 (+)
PWK/PhJ	MGP_PWKPhJ_G0024144	protein coding gene	Chr19:43238515-43248364 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023948	protein coding gene	Chr19:43662343-43672712 (+)
WSB/EiJ	MGP_WSBEiJ_G0024465	protein coding gene	Chr19:45147880-45157566 (+)

Human Ortholog

NOLC1, nucleolar and coiled-body phosphoprotein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOLC1, nucleolar and coiled-body phosphoprotein 1
Synonyms

NOPP130, NOPP140, NS5ATP13, P130, Srp40
Links

HGNC:15608

NCBI Gene ID: 9221

neXtProt AC: NX_Q14978

UniProt: Q14978
Chr Location

10q24.32; chr10:102152176-102163871 (+) GRCh38

MGI Vertebrate Homology

Nolc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOLC1
Gene Tree

Nolc1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Endonuclease-mediated

2
Gene trapped

43
Targeted

4
Genomic Mutations

1 involving Nolc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

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All GO Annotations

38
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NOLC1

Xenbase nolc1

ZFIN nolc1

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All Sequences

75
RefSeq

8
UniProt

6
CCDS

CCDS38006.1, CCDS89405.1, CCDS89406.1

Ensembl

ENSMUSG00000015176 (Evidence)
NCBI Gene

70769

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015176	Ensembl Gene Model \| MGI Sequence Detail	9668	C57BL/6J	± kb
transcript	ENSMUST00000165017	Ensembl \| MGI Sequence Detail	3634	Not Applicable
polypeptide	ENSMUSP00000128331	Ensembl \| MGI Sequence Detail	702	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011316 nucleolar phosphoprotein p130

(term hierarchy)
InterPro Domains

IPR006594 LIS1 homology motif

IPR039191 Nopp140-like

IPR007718 Srp40, C-terminal
GlyGen

E9Q5C9 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 17

Microarray probesets 5

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MGI:2147430, MGI:2147448, MGI:2147663

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nolc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156709	Chr19:46064281-46064298 (+)	-12 bp
Tssr156710	Chr19:46064378-46064385 (+)	80 bp
Tssr156711	Chr19:46064417-46064430 (+)	122 bp
Tssr156712	Chr19:46064438-46064459 (+)	147 bp
Tssr156713	Chr19:46071504-46071515 (+)	7,208 bp
Tssr156714	Chr19:46071548-46071561 (+)	7,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24