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Hars2 Gene Detail
Summary
  • Symbol
    Hars2
  • Name
    histidyl-tRNA synthetase 2
  • Synonyms
    4631412B19Rik, Harsl, HARSR, HO3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918041
    NCBI Gene: 70791
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36916257-36925615 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918041
 protein coding gene Chr18:36916061-36925615 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024292
 protein coding gene Chr18:35197172-35208282 (+)
A/J MGP_AJ_G0024258
 protein coding gene Chr18:33958185-33967756 (+)
AKR/J MGP_AKRJ_G0024226
 protein coding gene Chr18:34921704-34931624 (+)
BALB/cJ MGP_BALBcJ_G0024258
 protein coding gene Chr18:34006626-34016567 (+)
C3H/HeJ MGP_C3HHeJ_G0024025
 protein coding gene Chr18:34975804-34985374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024699
 protein coding gene Chr18:36434475-36446430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022139
 protein coding gene Chr18:34050207-34059586 (+)
CAST/EiJ MGP_CASTEiJ_G0023500
 protein coding gene Chr18:34991327-35000740 (+)
CBA/J MGP_CBAJ_G0023993
 protein coding gene Chr18:37512171-37521779 (+)
DBA/2J MGP_DBA2J_G0024125
 protein coding gene Chr18:33573716-33584357 (+)
FVB/NJ MGP_FVBNJ_G0024092
 protein coding gene Chr18:33284438-33293997 (+)
LP/J MGP_LPJ_G0024207
 protein coding gene Chr18:35229612-35239906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024120
 protein coding gene Chr18:38725135-38735962 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024748
 protein coding gene Chr18:34781916-34792262 (+)
PWK/PhJ MGP_PWKPhJ_G0023244
 protein coding gene Chr18:33836312-33845948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023051
 protein coding gene Chr18:35034899-35044273 (+)
WSB/EiJ MGP_WSBEiJ_G0023563
 protein coding gene Chr18:34704648-34716662 (+)



Homology
more
  • Human Ortholog
    HARS2, histidyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HARS2, histidyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    HARSL, HARSR, HisRS, HO3, PRLTS2
  • Links
    NCBI Gene ID: 23438
    neXtProt AC: NX_P49590
    UniProt: P49590

  • Chr Location
    5q31.3; chr5:140691430-140699305 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    96
  • cDNA Data
    57
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70791 NCBI Gene Model | MGI Sequence Detail 9359 C57BL/6J ±  kb
    transcript NM_001360921 RefSeq | MGI Sequence Detail 3146 C57BL/6  
    polypeptide Q99KK9 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029775 histidine--tRNA ligase, mitochondrial
      (term hierarchy)
    • EC
      6.1.1.21
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR004154 Anticodon-binding
      IPR036621 Anticodon-binding domain superfamily
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR041715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain
      IPR015807 Histidine-tRNA ligase
      IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
      IPR033656 Histidyl-anticodon-binding
    • GlyGen
      Q99KK9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147244
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory