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P2ry12 Gene Detail
Summary
  • Symbol
    P2ry12
  • Name
    purinergic receptor P2Y, G-protein coupled 12
  • Synonyms
    2900079B22Rik, 4921504D23Rik, P2Y12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918089
    NCBI Gene: 70839
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59123693-59170292 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1356 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918089
 protein coding gene Chr3:59123692-59170408 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027246
 protein coding gene Chr3:58095325-58142195 (-)
A/J MGP_AJ_G0027206
 protein coding gene Chr3:56277034-56323785 (-)
AKR/J MGP_AKRJ_G0027176
 protein coding gene Chr3:57448454-57497159 (-)
BALB/cJ MGP_BALBcJ_G0027219
 protein coding gene Chr3:56084360-56131207 (-)
C3H/HeJ MGP_C3HHeJ_G0026962
 protein coding gene Chr3:57668358-57713758 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027665
 protein coding gene Chr3:60233616-60281804 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025019
 protein coding gene Chr3:52636364-52681878 (-)
CAST/EiJ MGP_CASTEiJ_G0026414
 protein coding gene Chr3:57837509-57891423 (-)
CBA/J MGP_CBAJ_G0026938
 protein coding gene Chr3:62227314-62280311 (-)
DBA/2J MGP_DBA2J_G0027072
 protein coding gene Chr3:55787971-55833726 (-)
FVB/NJ MGP_FVBNJ_G0027040
 protein coding gene Chr3:54739193-54784365 (-)
LP/J MGP_LPJ_G0027184
 protein coding gene Chr3:58852610-58898579 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027058
 protein coding gene Chr3:66375112-66424707 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027723
 protein coding gene Chr3:57414070-57463127 (-)
PWK/PhJ MGP_PWKPhJ_G0026146
 protein coding gene Chr3:55417277-55463551 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025959
 protein coding gene Chr3:57121287-57168689 (-)
WSB/EiJ MGP_WSBEiJ_G0026488
 protein coding gene Chr3:57494330-57543173 (-)



Homology
more
  • Human Ortholog
    P2RY12, purinergic receptor P2Y12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY12, purinergic receptor P2Y12
  • Synonyms
    ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), SP1999
  • Links
    NCBI Gene ID: 64805
    neXtProt AC: NX_Q9H244
    UniProt: Q9H244

  • Chr Location
    3q25.1; chr3:151336843-151384753 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with P2ry12 mouse models; 5 with human P2RY12 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired platelet activation, increased bleeding time and delayed thrombus formation in injured arteries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    14
  • cDNA Data
    14
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036353 Ensembl Gene Model | MGI Sequence Detail 46600 C57BL/6J ±  kb
transcript ENSMUST00000170388 Ensembl | MGI Sequence Detail 2101 Not Applicable  
polypeptide ENSMUSP00000126819 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGI:1920308
References
more
  • Summaries
    All 126
    Developmental Gene Expression 20
    Diseases 3
    Gene Ontology 10
    Phenotypes 64
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:354190 Morimoto K, et al., Maternal immunoglobulins are distributed in the offspring's brain to support the maintenance of cortical interneurons in the postnatal period. Inflamm Regen. 2024 May 15;44(1):24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory