Spata16 MGI Mouse Gene Detail - MGI:1918112 - spermatogenesis associated 16

Symbol

Spata16
Name

spermatogenesis associated 16
Synonyms

4921511F01Rik, 4930503K02Rik, Nyd-sp12, spermatogenesis-related protein

Feature Type

protein coding gene
IDs

MGI:1918112
NCBI Gene: 70862
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:26691769-27037361 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 10.74 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

8475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918112	protein coding gene	Chr3:26691769-27037398 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027107	protein coding gene	Chr3:23935857-24286929 (+)
A/J	MGP_AJ_G0027067	protein coding gene	Chr3:23785461-24124964 (+)
AKR/J	MGP_AKRJ_G0027036	protein coding gene	Chr3:24073261-24413336 (+)
BALB/cJ	MGP_BALBcJ_G0027079	protein coding gene	Chr3:23459111-23791454 (+)
C3H/HeJ	MGP_C3HHeJ_G0026820	protein coding gene	Chr3:24093709-24458776 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027524	protein coding gene	Chr3:25275958-25636595 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024886	protein coding gene	Chr3:21839583-22145771 (+)
CAST/EiJ	MGP_CASTEiJ_G0026275	protein coding gene	Chr3:23933015-24284929 (+)
CBA/J	MGP_CBAJ_G0026798	protein coding gene	Chr3:25915397-26293822 (+)
DBA/2J	MGP_DBA2J_G0026932	protein coding gene	Chr3:23335867-23671581 (+)
FVB/NJ	MGP_FVBNJ_G0026900	protein coding gene	Chr3:22821350-23149334 (+)
LP/J	MGP_LPJ_G0027044	protein coding gene	Chr3:24622280-24967067 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026921	protein coding gene	Chr3:28546821-28914421 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027584	protein coding gene	Chr3:23772120-24130534 (+)
PWK/PhJ	MGP_PWKPhJ_G0026008	protein coding gene	Chr3:22812787-23133446 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025818	protein coding gene	Chr3:23351957-23691162 (+)
WSB/EiJ	MGP_WSBEiJ_G0026348	protein coding gene	Chr3:23824711-24166898 (+)

Human Ortholog

SPATA16, spermatogenesis associated 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATA16, spermatogenesis associated 16
Synonyms

NYD-SP12, SPGF6
Links

HGNC:29935

NCBI Gene ID: 83893

neXtProt AC: NX_Q9BXB7

UniProt: Q9BXB7
Chr Location

3q26.31; chr3:172889357-173141235 (-) GRCh38

MGI Vertebrate Homology

Spata16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPATA16
Gene Tree

Spata16

Diseases

1 with Spata16 mouse models; 1 with human SPATA16 associations

Human Disease

Mouse Models

male infertility

IDs

View 1 model

spermatogenic failure 6

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Spata16
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a deletion of the fourth exon exhibit male infertility mice due to spermiogenic arrest but not globozoospermia.

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All GO Annotations

7
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

6
UniProt

1
CCDS

CCDS17269.1, CCDS38403.1

Ensembl

ENSMUSG00000039335 (Evidence)
NCBI Gene

70862

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039335	Ensembl Gene Model \| MGI Sequence Detail	345593	C57BL/6J	± kb
transcript	ENSMUST00000047005	Ensembl \| MGI Sequence Detail	2022	Not Applicable
polypeptide	ENSMUSP00000043378	Ensembl \| MGI Sequence Detail	571	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015481 spermatogenesis-associated protein 16

(term hierarchy)
InterPro Domains

IPR029161 Spermatogenesis-associated protein 16

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:1922288

Summaries

All 30

Diseases 2

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Spata16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28597	Chr3:26691767-26691786 (+)	8 bp
Tssr28598	Chr3:26691795-26691809 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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