Garin2 MGI Mouse Gene Detail - MGI:1918147 - golgi associated RAB2 interactor 2

Symbol

Garin2
Name

golgi associated RAB2 interactor 2
Synonyms

4921509E07Rik, 4930516C23Rik, Fam71d

Feature Type

protein coding gene
IDs

MGI:1918147
NCBI Gene: 70897
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:78738309-78781290 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

829 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918147	protein coding gene	Chr12:78738257-78781290 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019871	protein coding gene	Chr12:78953620-78999141 (+)
A/J	MGP_AJ_G0019829	protein coding gene	Chr12:76122679-76164352 (+)
AKR/J	MGP_AKRJ_G0019804	protein coding gene	Chr12:78186600-78228126 (+)
BALB/cJ	MGP_BALBcJ_G0019808	protein coding gene	Chr12:76370877-76414802 (+)
C3H/HeJ	MGP_C3HHeJ_G0019614	protein coding gene	Chr12:78647401-78691456 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020260	protein coding gene	Chr12:81289150-81337278 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017878	protein coding gene	Chr12:73149530-73189269 (+)
CAST/EiJ	MGP_CASTEiJ_G0019164	protein coding gene	Chr12:73477877-73521997 (+)
CBA/J	MGP_CBAJ_G0019584	protein coding gene	Chr12:84464382-84506504 (+)
DBA/2J	MGP_DBA2J_G0019700	protein coding gene	Chr12:75749309-75787275 (+)
FVB/NJ	MGP_FVBNJ_G0019686	protein coding gene	Chr12:74560856-74600879 (+)
LP/J	MGP_LPJ_G0019772	protein coding gene	Chr12:78885291-78928254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019725	protein coding gene	Chr12:87503861-87550032 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020296	protein coding gene	Chr12:77694277-77739845 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0018724	protein coding gene	Chr12:72200815-72244086 (+)
WSB/EiJ	MGP_WSBEiJ_G0019217	protein coding gene	Chr12:78299599-78343498 (+)

Human Ortholog

GARIN2, golgi associated RAB2 interactor family member 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GARIN2, golgi associated RAB2 interactor family member 2
Synonyms

C14orf54, FAM71D, GARI-L1, GARI-L2
Links

HGNC:20101

NCBI Gene ID: 161142

neXtProt AC: NX_Q8N9W8

UniProt: Q8N9W8
Chr Location

14q23.3; chr14:67189393-67228558 (+) GRCh38

MGI Vertebrate Homology

Garin2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GARIN2
Gene Tree

Garin2

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Garin2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

While one homozygous null allele shows no gross physical abnormalities and normal male fertility, with normal testes, sperm counts, sperm motility and spermatogenesis, another knock-out allele shows small testes in males and enlarged spleen and thymus in females.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

102
RefSeq

53
UniProt

7
CCDS

CCDS49096.1, CCDS88358.1

Ensembl

ENSMUSG00000056987 (Evidence)
NCBI Gene

70897

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056987	Ensembl Gene Model \| MGI Sequence Detail	42982	C57BL/6J	± kb
transcript	ENSMUST00000077968	Ensembl \| MGI Sequence Detail	1772	Not Applicable
polypeptide	ENSMUSP00000077119	Ensembl \| MGI Sequence Detail	440	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000030917 Golgi-associated RAB2 interactor protein 2

(term hierarchy)
InterPro Domains

IPR022168 Golgi associated RAB2 interactor protein-like, Rab2B-binding domain

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:1921969, MGI:6885578

Summaries

All 31

Gene Ontology 2

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:350937 Wang H, et al., Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS Genet. 2024 Jun;20(6):e1011337

TSS for Garin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114056	Chr12:78738269-78738286 (+)	-31 bp
Tssr114057	Chr12:78738290-78738314 (+)	-7 bp
Tssr114058	Chr12:78738425-78738464 (+)	136 bp
Tssr114059	Chr12:78770314-78770317 (+)	32,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24