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Nsun7 Gene Detail
Summary
  • Symbol
    Nsun7
  • Name
    NOL1/NOP2/Sun domain family, member 7
  • Synonyms
    4921525L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918168
    NCBI Gene: 70918
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:66417240-66455369 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 34.34 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    958 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918168
 protein coding gene Chr5:66417181-66457544 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029588
 protein coding gene Chr5:65986622-66026629 (+)
A/J MGP_AJ_G0029556
 protein coding gene Chr5:63506668-63547416 (+)
AKR/J MGP_AKRJ_G0029504
 protein coding gene Chr5:65550468-65592987 (+)
BALB/cJ MGP_BALBcJ_G0029565
 protein coding gene Chr5:64199106-64237958 (+)
C3H/HeJ MGP_C3HHeJ_G0029288
 protein coding gene Chr5:65869614-65911819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030019
 protein coding gene Chr5:68717393-68766177 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027259
 protein coding gene Chr5:59573189-59612499 (+)
CAST/EiJ MGP_CASTEiJ_G0028696
 protein coding gene Chr5:65028426-65068361 (+)
CBA/J MGP_CBAJ_G0029257
 protein coding gene Chr5:70930151-70975677 (+)
DBA/2J MGP_DBA2J_G0029403
 protein coding gene Chr5:63532626-63572798 (+)
FVB/NJ MGP_FVBNJ_G0029363
 protein coding gene Chr5:62713802-62754340 (+)
LP/J MGP_LPJ_G0029488
 protein coding gene Chr5:66477627-66517873 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029391
 protein coding gene Chr5:73760063-73805334 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030052
 protein coding gene Chr5:65204715-65245701 (+)
PWK/PhJ MGP_PWKPhJ_G0028420
 protein coding gene Chr5:62540833-62580038 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028254
 protein coding gene Chr5:64566974-64608537 (+)
WSB/EiJ MGP_WSBEiJ_G0028776
 protein coding gene Chr5:65434727-65474639 (+)



Homology
more
  • Human Ortholog
    NSUN7, NOP2/Sun RNA methyltransferase family member 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSUN7, NOP2/Sun RNA methyltransferase family member 7
  • Links
    NCBI Gene ID: 79730
    neXtProt AC: NX_Q8NE18
    UniProt: Q8NE18

  • Chr Location
    4p14; chr4:40749925-40811184 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for an ENU-induced mutation are either infertile or subfertile. Mutant sperm exhibit poor progressive motility linked to rigidity of the flagellar midpiece and abnormal electron density patterns in the mitochondrial sheath.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    866
  • Tissues
    68
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029206 Ensembl Gene Model | MGI Sequence Detail 38130 C57BL/6J ±  kb
    transcript ENSMUST00000031109 Ensembl | MGI Sequence Detail 2345 Not Applicable  
    polypeptide ENSMUSP00000031109 Ensembl | MGI Sequence Detail 705 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031628 putative methyltransferase NSUN7
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR049561 NOL1/NOP2/NSUN 5/7, ferredoxin-like domain
      IPR042620 Putative methyltransferase NSUN7
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR049560 SAM-dependent methyltransferase RsmB-F/NOP2-type, catalytic core
      IPR001678 SAM-dependent methyltransferase RsmB-F/NOP2-type domain
    • GlyGen
      Q14AW5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory