Trim45 MGI Mouse Gene Detail - MGI:1918187 - tripartite motif-containing 45

Symbol

Trim45
Name

tripartite motif-containing 45
Synonyms

4921530N01Rik

Feature Type

protein coding gene
IDs

MGI:1918187
NCBI Gene: 229644
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:100829518-100844236 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.85 cM
Mapping Data

2 experiments

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918187	protein coding gene	Chr3:100828516-100844241 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027670	protein coding gene	Chr3:102058650-102074630 (+)
A/J	MGP_AJ_G0027629	protein coding gene	Chr3:98843933-98858575 (+)
AKR/J	MGP_AKRJ_G0027595	protein coding gene	Chr3:101266435-101281167 (+)
BALB/cJ	MGP_BALBcJ_G0027642	protein coding gene	Chr3:98604261-98618921 (+)
C3H/HeJ	MGP_C3HHeJ_G0027371	protein coding gene	Chr3:101562427-101577173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028085	protein coding gene	Chr3:105803713-105820170 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025426	protein coding gene	Chr3:95039446-95054114 (+)
CAST/EiJ	MGP_CASTEiJ_G0026827	protein coding gene	Chr3:100659240-100673816 (+)
CBA/J	MGP_CBAJ_G0027346	protein coding gene	Chr3:109449577-109464362 (+)
DBA/2J	MGP_DBA2J_G0027489	protein coding gene	Chr3:98082727-98097502 (+)
FVB/NJ	MGP_FVBNJ_G0027457	protein coding gene	Chr3:96015854-96031077 (+)
LP/J	MGP_LPJ_G0027596	protein coding gene	Chr3:103422050-103437702 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027487	protein coding gene	Chr3:115674827-115689557 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028140	protein coding gene	Chr3:100755035-100769711 (+)
PWK/PhJ	MGP_PWKPhJ_G0026554	protein coding gene	Chr3:97838066-97852933 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026376	protein coding gene	Chr3:98852958-98866781 (+)
WSB/EiJ	MGP_WSBEiJ_G0026907	protein coding gene	Chr3:101318245-101334437 (+)

Human Ortholog

TRIM45, tripartite motif containing 45

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM45, tripartite motif containing 45
Synonyms

RNF99
Links

HGNC:19018

NCBI Gene ID: 80263

neXtProt AC: NX_Q9H8W5

UniProt: Q9H8W5
Chr Location

1p13.1; chr1:117111060-117123927 (-) GRCh38

MGI Vertebrate Homology

Trim45 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIM45
Gene Tree

Trim45

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Trim45
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

34
cDNA Data

22
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim45

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All Sequences

47
RefSeq

10
UniProt

2
CCDS

CCDS17678.1, CCDS51018.1

Ensembl

ENSMUSG00000033233 (Evidence)
NCBI Gene

229644

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033233	Ensembl Gene Model \| MGI Sequence Detail	14719	C57BL/6J	± kb
transcript	ENSMUST00000134993	Ensembl \| MGI Sequence Detail	2274	Not Applicable
polypeptide	ENSMUSP00000115669	Ensembl \| MGI Sequence Detail	757	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016659 E3 ubiquitin-protein ligase TRIM45

(term hierarchy)
PDB

8SDI
EC

2.3.2.27
InterPro Domains

IPR003649 B-box, C-terminal

IPR000315 B-box-type zinc finger

IPR001298 Filamin/ABP280 repeat

IPR017868 Filamin/ABP280 repeat-like

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR047153 TRIM45/56/19

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 22

cDNA 22

Microarray probesets 2

Summaries

All 42

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trim45:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30884	Chr3:100828091-100828099 (+)	-1,423 bp
Tssr30885	Chr3:100829008-100829018 (+)	-505 bp
Tssr30886	Chr3:100829752-100829789 (+)	253 bp
Tssr30887	Chr3:100829798-100829815 (+)	289 bp
Tssr30888	Chr3:100832244-100832262 (+)	2,735 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24