Cabs1 MGI Mouse Gene Detail - MGI:1918227 - calcium binding protein, spermatid specific 1

Symbol

Cabs1
Name

calcium binding protein, spermatid specific 1
Synonyms

4931407G18Rik

Feature Type

protein coding gene
IDs

MGI:1918227
NCBI Gene: 70977
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:88127310-88129400 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918227	protein coding gene	Chr5:88127298-88129403 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029698	protein coding gene	Chr5:88958426-88960531 (+)
A/J	MGP_AJ_G0029665	protein coding gene	Chr5:85327217-85329322 (+)
AKR/J	MGP_AKRJ_G0029611	protein coding gene	Chr5:88150025-88152130 (+)
BALB/cJ	MGP_BALBcJ_G0029674	protein coding gene	Chr5:86248331-86250436 (+)
C3H/HeJ	MGP_C3HHeJ_G0029397	protein coding gene	Chr5:88546284-88548389 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030129	protein coding gene	Chr5:92603691-92605796 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027367	protein coding gene	Chr5:80924591-80926688 (+)
CAST/EiJ	MGP_CASTEiJ_G0028807	protein coding gene	Chr5:87951662-87953767 (+)
CBA/J	MGP_CBAJ_G0029366	protein coding gene	Chr5:95537107-95539212 (+)
DBA/2J	MGP_DBA2J_G0029511	protein coding gene	Chr5:85494356-85496461 (+)
FVB/NJ	MGP_FVBNJ_G0029471	protein coding gene	Chr5:84402586-84404691 (+)
LP/J	MGP_LPJ_G0029599	protein coding gene	Chr5:89367347-89369452 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029500	protein coding gene	Chr5:100669490-100672437 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030162	protein coding gene	Chr5:87715781-87717886 (+)
PWK/PhJ	MGP_PWKPhJ_G0028526	protein coding gene	Chr5:84492510-84494699 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028363	protein coding gene	Chr5:87128738-87130843 (+)
WSB/EiJ	MGP_WSBEiJ_G0028886	protein coding gene	Chr5:88107835-88109937 (+)

Human Ortholog

CABS1, calcium binding protein, spermatid associated 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CABS1, calcium binding protein, spermatid associated 1
Synonyms

C4orf35, CLPH, NYD-SP26
Links

HGNC:30710

NCBI Gene ID: 85438

neXtProt AC: NX_Q96KC9

UniProt: Q96KC9
Chr Location

4q13.3; chr4:70334981-70337116 (+) GRCh38

MGI Vertebrate Homology

Cabs1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CABS1
Gene Tree

Cabs1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Genomic Mutations

4 involving Cabs1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit bent sperm tails, thinning annulus, reduced sperm motility, and reduced pregnancy rates.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS39136.1

Ensembl

ENSMUSG00000007907 (Evidence)
NCBI Gene

70977

			Length	Strain/Species	Flank
genomic	70977	NCBI Gene Model \| MGI Sequence Detail	2091	C57BL/6J	± kb
transcript	NM_027631	RefSeq \| MGI Sequence Detail	1490	C57BL/6
polypeptide	Q8C633	UniProt \| EBI \| MGI Sequence Detail	391	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005600 calcium-binding and spermatid-specific protein 1

(term hierarchy)
InterPro Domains

IPR026118 Calcium-binding and spermatid-specific protein 1
GlyGen

Q8C633 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:2140871

Summaries

All 34

Gene Ontology 6

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345792 Cai H, et al., CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression. Nat Commun. 2024 Mar 7;15(1):2088

TSS for Cabs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46963	Chr5:88127291-88127317 (+)	-6 bp
Tssr46964	Chr5:88127329-88127336 (+)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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