Mex3b MGI Mouse Gene Detail - MGI:1918252 - mex3 RNA binding family member B

Symbol

Mex3b
Name

mex3 RNA binding family member B
Synonyms

4931439A04Rik, Rkhd3

Feature Type

protein coding gene
IDs

MGI:1918252
NCBI Gene: 108797
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:82516541-82520723 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 47.35 cM
Mapping Data

3 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918252	protein coding gene	Chr7:82516541-82520784 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032446	protein coding gene	Chr7:85005886-85011184 (+)
A/J	MGP_AJ_G0032424	protein coding gene	Chr7:82962010-82966054 (+)
AKR/J	MGP_AKRJ_G0032360	protein coding gene	Chr7:84845166-84849210 (+)
BALB/cJ	MGP_BALBcJ_G0032436	protein coding gene	Chr7:82626790-82630834 (+)
C3H/HeJ	MGP_C3HHeJ_G0032150	protein coding gene	Chr7:85410151-85414192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032927	protein coding gene	Chr7:88300788-88305018 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029937	protein coding gene	Chr7:85387102-85391323 (+)
CAST/EiJ	MGP_CASTEiJ_G0031477	protein coding gene	Chr7:76378344-76382577 (+)
CBA/J	MGP_CBAJ_G0032115	protein coding gene	Chr7:91234259-91238300 (+)
DBA/2J	MGP_DBA2J_G0032270	protein coding gene	Chr7:81471229-81475270 (+)
FVB/NJ	MGP_FVBNJ_G0032224	protein coding gene	Chr7:81432414-81436535 (+)
LP/J	MGP_LPJ_G0032351	protein coding gene	Chr7:86217152-86221421 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032261	protein coding gene	Chr7:91278087-91282954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032947	protein coding gene	Chr7:84250725-84254956 (+)
PWK/PhJ	MGP_PWKPhJ_G0031197	protein coding gene	Chr7:74696248-74700472 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031039	protein coding gene	Chr7:71241048-71245288 (+)
WSB/EiJ	MGP_WSBEiJ_G0031594	protein coding gene	Chr7:84615700-84619932 (+)

Human Ortholog

MEX3B, mex-3 RNA binding family member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEX3B, mex-3 RNA binding family member B
Synonyms

MEX-3B, RKHD3, RNF195
Links

HGNC:25297

NCBI Gene ID: 84206

neXtProt AC: NX_Q6ZN04

UniProt: Q6ZN04
Chr Location

15q25.2; chr15:82041778-82046119 (-) GRCh38

MGI Vertebrate Homology

Mex3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEX3B
Gene Tree

Mex3b

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Phenotype Summary

26 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

6
Genomic Mutations

3 involving Mex3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to partial neonatal lethality, decreased body weight and subfertility. Males show seminiferous tubule obstruction, oligozoospermia, abnormalities in Sertoli cell barrier morphology and function, and impaired Sertoli cell and macrophage phagocytosis.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

61
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mex3b

ZFIN mex3b

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All Sequences

38
RefSeq

2
UniProt

3
CCDS

CCDS52286.1

Ensembl

ENSMUSG00000057706 (Evidence)
NCBI Gene

108797

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057706	Ensembl Gene Model \| MGI Sequence Detail	4183	C57BL/6J	± kb
transcript	ENSMUST00000082237	Ensembl \| MGI Sequence Detail	3355	Not Applicable
polypeptide	ENSMUSP00000082168	Ensembl \| MGI Sequence Detail	576	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010357 RNA-binding protein MEX3B

(term hierarchy)
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR047227 RNA-binding protein MEX3

IPR047228 RNA-binding protein MEX-3, first type I KH domain

IPR047226 RNA-binding protein MEX-3, second type I KH domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q69Z36 1 site, 1 N-linked glycan (1 site)

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 4

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MGI:1934873

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 21
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mex3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67560	Chr7:82516414-82516425 (+)	-121 bp
Tssr67561	Chr7:82516512-82516521 (+)	-24 bp
Tssr67562	Chr7:82516535-82516565 (+)	9 bp
Tssr67563	Chr7:82516659-82516707 (+)	142 bp
Tssr2317	Chr7:82516992-82517002 (+)	456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24