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Spem2 Gene Detail
Summary
  • Symbol
    Spem2
  • Name
    SPEM family member 2
  • Synonyms
    4933402P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918293
    NCBI Gene: 108803
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69707392-69709291 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918293
 protein coding gene Chr11:69707386-69709313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018557
 protein coding gene Chr11:70299757-70301656 (-)
A/J MGP_AJ_G0018525
 protein coding gene Chr11:67637253-67639152 (-)
AKR/J MGP_AKRJ_G0018494
 protein coding gene Chr11:69656583-69658482 (-)
BALB/cJ MGP_BALBcJ_G0018497
 protein coding gene Chr11:67964647-67966546 (-)
C3H/HeJ MGP_C3HHeJ_G0018310
 protein coding gene Chr11:69689221-69691120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018948
 protein coding gene Chr11:72420486-72422385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016593
 protein coding gene Chr11:64559895-64561786 (-)
CAST/EiJ MGP_CASTEiJ_G0017865
 protein coding gene Chr11:69928047-69929943 (-)
CBA/J MGP_CBAJ_G0018283
 protein coding gene Chr11:75661855-75663754 (-)
DBA/2J MGP_DBA2J_G0018392
 protein coding gene Chr11:67220834-67222732 (-)
FVB/NJ MGP_FVBNJ_G0018382
 protein coding gene Chr11:66861159-66863057 (-)
LP/J MGP_LPJ_G0018462
 protein coding gene Chr11:70860984-70862883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018405
 protein coding gene Chr11:76269150-76271049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018990
 protein coding gene Chr11:69919708-69921607 (-)
PWK/PhJ MGP_PWKPhJ_G0017639
 protein coding gene Chr11:67870468-67872366 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017429
 protein coding gene Chr11:69740032-69741929 (-)
WSB/EiJ MGP_WSBEiJ_G0017919
 protein coding gene Chr11:69587671-69589570 (-)



Homology
more
  • Human Ortholog
    SPEM2, SPEM family member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPEM2, SPEM family member 2
  • Synonyms
    C17orf74
  • Links
    NCBI Gene ID: 201243
    neXtProt AC: NX_Q0P670
    UniProt: Q0P670

  • Chr Location
    17p13.1; chr17:7425616-7427568 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show male sterility, teratozoospermia, oligozoospermia, asthenozoospermia, impaired fertilization, and multiple abnormalities in spermiogenesis, including abnormal acrosome biogenesis, failure of excess cytoplasm shedding, and impaired sperm individualization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044084 Ensembl Gene Model | MGI Sequence Detail 1900 C57BL/6J ±  kb
    transcript ENSMUST00000056941 Ensembl | MGI Sequence Detail 1640 Not Applicable  
    polypeptide ENSMUSP00000051204 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5906010
    References
    more
    • Summaries
      All 28
      Gene Ontology 1
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354200 Li C, et al., Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice. Cell Mol Life Sci. 2024 Feb 29;81(1):108
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory