Zfp597 MGI Mouse Gene Detail - MGI:1918313

Symbol

Zfp597
Name

zinc finger protein 597
Synonyms

4933407K12Rik

Feature Type

protein coding gene
IDs

MGI:1918313
NCBI Gene: 71063
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:3679408-3702241 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.27 cM
Mapping Data

2 experiments

SNPs within 2kb

493 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918313	protein coding gene	Chr16:3676185-3702425 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022452	protein coding gene	Chr16:298551-327519 (-)
A/J	MGP_AJ_G0022413	protein coding gene	Chr16:180277-206377 (-)
AKR/J	MGP_AKRJ_G0022390	protein coding gene	Chr16:320583-348241 (-)
BALB/cJ	MGP_BALBcJ_G0022418	protein coding gene	Chr16:307165-333710 (-)
C3H/HeJ	MGP_C3HHeJ_G0022185	protein coding gene	Chr16:354154-379887 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022867	protein coding gene	Chr16:338519-364675 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020389	protein coding gene	Chr16:131310-158898 (-)
CAST/EiJ	MGP_CASTEiJ_G0021712	protein coding gene	Chr16:307723-337303 (-)
CBA/J	MGP_CBAJ_G0022154	protein coding gene	Chr16:400629-431727 (-)
DBA/2J	MGP_DBA2J_G0022285	protein coding gene	Chr16:288853-316274 (-)
FVB/NJ	MGP_FVBNJ_G0022261	protein coding gene	Chr16:260113-286192 (-)
LP/J	MGP_LPJ_G0022354	protein coding gene	Chr16:310926-337453 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022283	protein coding gene	Chr16:293989-324818 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022879	protein coding gene	Chr16:283731-310613 (-)
PWK/PhJ	MGP_PWKPhJ_G0021452	protein coding gene	Chr16:324242-351316 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021283	protein coding gene	Chr16:387149-414306 (-)
WSB/EiJ	MGP_WSBEiJ_G0021761	protein coding gene	Chr16:314824-343813 (-)

Human Ortholog

ZNF597, zinc finger protein 597

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF597, zinc finger protein 597
Synonyms

HIT-4
Links

HGNC:26573

NCBI Gene ID: 146434

neXtProt AC: NX_Q96LX8

UniProt: Q96LX8
Chr Location

16p13.3; chr16:3432414-3443504 (-) GRCh38

MGI Vertebrate Homology

Zfp597 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF597
Gene Tree

Zfp597

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality with a developmental arrest at the egg cylinder stage. Adult heterozygotes show ataxic or epileptic behaviors, spongiform pathology and neurodegeneration in the dorsal striatum and deep cortical layers.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

31
cDNA Data

40
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS27911.1

Ensembl

ENSMUSG00000039789 (Evidence)
NCBI Gene

71063

			Length	Strain/Species	Flank
genomic	71063	NCBI Gene Model \| MGI Sequence Detail	22834	C57BL/6J	± kb
transcript	NM_001033159	RefSeq \| MGI Sequence Detail	5630	C57BL/6
polypeptide	NP_001028331	RefSeq \| MGI Sequence Detail	419	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 40

cDNA 40

Microarray probesets 7

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MGI:2146438, MGI:2146479

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp597:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139731	Chr16:3702336-3702436 (-)	-145 bp
Tssr139730	Chr16:3702302-3702334 (-)	-77 bp
Tssr139729	Chr16:3690242-3690275 (-)	11,982 bp
Tssr139728	Chr16:3690150-3690179 (-)	12,076 bp
Tssr139727	Chr16:3690119-3690147 (-)	12,108 bp
Tssr139726	Chr16:3690095-3690113 (-)	12,137 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24