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Rimklb Gene Detail
Summary
  • Symbol
    Rimklb
  • Name
    ribosomal modification protein rimK-like family member B
  • Synonyms
    4931417E21Rik, 4933426K21Rik, NAAGS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918325
    NCBI Gene: 108653
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122424255-122464021 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.55 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    945 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918325
 protein coding gene Chr6:122424255-122475720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031226
 protein coding gene Chr6:125533864-125587915 (-)
A/J MGP_AJ_G0031195
 protein coding gene Chr6:120784848-120836850 (-)
AKR/J MGP_AKRJ_G0031124
 protein coding gene Chr6:124122791-124176529 (-)
BALB/cJ MGP_BALBcJ_G0031204
 protein coding gene Chr6:120466712-120520156 (-)
C3H/HeJ MGP_C3HHeJ_G0030923
 protein coding gene Chr6:124071666-124123131 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031663
 protein coding gene Chr6:128818548-128872866 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028822
 protein coding gene Chr6:117395206-117413719 (-)
CAST/EiJ MGP_CASTEiJ_G0030313
 protein coding gene Chr6:124337487-124390193 (-)
CBA/J MGP_CBAJ_G0030887
 protein coding gene Chr6:133853696-133906941 (-)
DBA/2J MGP_DBA2J_G0031043
 protein coding gene Chr6:119699725-119750982 (-)
FVB/NJ MGP_FVBNJ_G0030995
 protein coding gene Chr6:118646010-118698747 (-)
LP/J MGP_LPJ_G0031123
 protein coding gene Chr6:125685892-125742135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031030
 protein coding gene Chr6:137824351-137881355 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031693
 protein coding gene Chr6:124015104-124068983 (-)
PWK/PhJ MGP_PWKPhJ_G0030027
 protein coding gene Chr6:118534439-118585810 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029854
 protein coding gene Chr6:122146230-122197851 (-)
WSB/EiJ MGP_WSBEiJ_G0030395
 protein coding gene Chr6:124320280-124374247 (-)



Homology
more
  • Human Ortholog
    RIMKLB, ribosomal modification protein rimK like family member B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMKLB, ribosomal modification protein rimK like family member B
  • Synonyms
    FAM80B, NAAGS, NAAGS-I
  • Links
    NCBI Gene ID: 57494
    neXtProt AC: NX_Q9ULI2
    UniProt: Q9ULI2

  • Chr Location
    12p13.31; chr12:8668638-8783095 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a 3 bp deletion exhibit male infertility, with decreased sperm counts, impaired sperm motility, sperm head abnormalities and incomplete spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    41
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108653 NCBI Gene Model | MGI Sequence Detail 39767 C57BL/6J ±  kb
    transcript NM_027664 RefSeq | MGI Sequence Detail 4017 C57BL/6  
    polypeptide Q80WS1 UniProt | EBI | MGI Sequence Detail 387 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1889811, MGI:1913991, MGI:2141551, MGI:3034764
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:348902 Becker I, et al., NAAG synthetase deficiency has only low influence on pathogenesis in a Canavan disease mouse model. J Inherit Metab Dis. 2024 Mar;47(2):230-243
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory