Stx18 MGI Mouse Gene Detail - MGI:1918366

Symbol

Stx18
Name

syntaxin 18
Synonyms

1810035L21Rik, 4933425D03Rik

Feature Type

protein coding gene
IDs

MGI:1918366
NCBI Gene: 71116
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:38196086-38295109 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 20.21 cM
Mapping Data

4 experiments

SNPs within 2kb

1833 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918366	protein coding gene	Chr5:38194073-38295114 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029505	protein coding gene	Chr5:36443618-36542162 (+)
A/J	MGP_AJ_G0029471	protein coding gene	Chr5:35220253-35315888 (+)
AKR/J	MGP_AKRJ_G0029421	protein coding gene	Chr5:36547369-36649353 (+)
BALB/cJ	MGP_BALBcJ_G0029482	protein coding gene	Chr5:35720039-35812488 (+)
C3H/HeJ	MGP_C3HHeJ_G0029205	protein coding gene	Chr5:36545996-36643135 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029936	protein coding gene	Chr5:38382295-38482471 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027174	protein coding gene	Chr5:32902914-32997845 (+)
CAST/EiJ	MGP_CASTEiJ_G0028613	protein coding gene	Chr5:35712408-35805960 (+)
CBA/J	MGP_CBAJ_G0029172	protein coding gene	Chr5:39299469-39398329 (+)
DBA/2J	MGP_DBA2J_G0029319	protein coding gene	Chr5:35344097-35436906 (+)
FVB/NJ	MGP_FVBNJ_G0029278	protein coding gene	Chr5:34827444-34924207 (+)
LP/J	MGP_LPJ_G0029405	protein coding gene	Chr5:36892132-36991154 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029308	protein coding gene	Chr5:40012675-40109330 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029969	protein coding gene	Chr5:36045557-36139354 (+)
PWK/PhJ	MGP_PWKPhJ_G0028337	protein coding gene	Chr5:34515313-34606219 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028171	protein coding gene	Chr5:35497149-35590591 (+)
WSB/EiJ	MGP_WSBEiJ_G0028694	protein coding gene	Chr5:36122239-36216306 (+)

Human Ortholog

STX18, syntaxin 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX18, syntaxin 18
Synonyms

Ufe1
Links

HGNC:15942

NCBI Gene ID: 53407

neXtProt AC: NX_Q9P2W9

UniProt: Q9P2W9
Chr Location

4p16.3-p16.2; chr4:4415742-4542346 (-) GRCh38

MGI Vertebrate Homology

Stx18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STX18
Gene Tree

Stx18

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Chemically induced (other)

2
Radiation induced

2
Spontaneous

1
Targeted

5
Genomic Mutations

6 involving Stx18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

40
cDNA Data

52
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stx18

ZFIN stx18

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All Sequences

64
RefSeq

12
UniProt

4
CCDS

CCDS19250.1, CCDS71583.1, CCDS80270.1

Ensembl

ENSMUSG00000029125 (Evidence)
NCBI Gene

71116

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029125	Ensembl Gene Model \| MGI Sequence Detail	99024	C57BL/6J	± kb
transcript	ENSMUST00000114126	Ensembl \| MGI Sequence Detail	3002	Not Applicable
polypeptide	ENSMUSP00000109761	Ensembl \| MGI Sequence Detail	334	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015790 syntaxin-18

(term hierarchy)
InterPro Domains

IPR019529 SNARE-complex protein Syntaxin-18, N-terminal

IPR006012 Syntaxin/epimorphin, conserved site

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All nucleic 52

cDNA 52

Microarray probesets 7

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MGI:1916395, MGI:2141082

Summaries

All 55

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 23
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stx18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46037	Chr5:38196541-38196563 (+)	466 bp
Tssr46038	Chr5:38196568-38196643 (+)	520 bp
Tssr46039	Chr5:38196648-38196666 (+)	571 bp
Tssr46040	Chr5:38233841-38233852 (+)	37,761 bp
Tssr46041	Chr5:38233863-38233878 (+)	37,785 bp
Tssr46042	Chr5:38233907-38233916 (+)	37,826 bp
Tssr46043	Chr5:38265486-38265494 (+)	69,404 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24